Evidence map›Paper›PMID 41038524›Full record

ArticleThe American journal of cardiology2026

Deep Learning Predicts Cardiac Output from Seismocardiographic Signals in Heart Failure.

Jesse Wang, Seyed M Nouraie, Neil J Kelly, Stephen Y Chan

Abstract read
In one paragraph

Article in The American journal of cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Jesse WangUniversity of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA; University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Seyed M NouraieUniversity of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA; Division of Pulmonary, Allergy Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Neil J KellyUniversity of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA; Heart and Vascular Institute; Pittsburgh VA Medical Center, Pittsburgh, Pennsylvania, USA. Electronic address: njk88@pitt.edu.
Stephen Y ChanUniversity of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA; University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA; Heart and Vascular Institute. Electronic address: chansy@pitt.edu.

Funding

Defining the Complex Biology of the miR-130/301 Family in Pulmonary HypertensionR01HL124021 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHAN, STEPHEN Y · 2014 to 2025
$4.9M
Training Program in Imaging Sciences in Translational Cardiovascular ResearchT32HL129964 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Flordeliza S Villanueva · 2016 to 2026
$4.7M
Iron-Sulfur Deficiency as a Critical Pathogenic Cause of Pulmonary HypertensionR01HL122596 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHAN, STEPHEN Y · 2015 to 2024
$4.5M
Genetic and hypoxic control of a lncRNA axis orchestrates endothelial reprogramming in pulmonary hypertensionR01HL151228 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Stephen Y Chan · 2023 to 2026
$2.8M
Airborne particulates exacerbate vascular remodeling in pulmonary hypertensionK08ES037420 · NIEHS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Neil Jeremiah Kelly · 2025 to 2026
$300k
NHLBI NIH HHS R01 HL122596NHLBI NIH HHS R01 HL124021NHLBI NIH HHS R01 HL151228NHLBI NIH HHS T32 HL129964NIEHS NIH HHS K08 ES037420
6 · The paper itself

Abstract

Determination of cardiac output (CO) is essential to the clinical management of cardiovascular compromise. However, the invasiveness, procedural risks, and reliance on specialized infrastructure limit accessibility and scalability of standard-of-care right heart catheterization (RHC). Seismocardiography (SCG), a non-invasive technique which records subtle chest wall vibrations generated by cardiac mechanical activity, may offer a promising alternative for CO determination. To explore this potential, we developed and evaluated a deep learning model for estimating CO directly from SCG, electrocardiogram (ECG), and body mass index (BMI) in heart failure patients undergoing RHC. We trained a deep convolutional neural network for CO estimation using an open-access dataset comprising 73 heart failure patients with simultaneous RHC, SCG, and ECG recordings. Model performance was evaluated on 64 patients using pairwise nested leave-pair-out cross-validation. When estimating CO in patients with a reference output < 6 L/min, the deep learning model achieved a mean bias of -0.01 L/min with LoA from -0.88 to 0.87 L/min. When predicting cardiac index in patients with a reference index < 2.2 L/min/m

Indexed as

Cardiac OutputDeep LearningHeart FailureAgedBody Mass IndexCardiac CatheterizationElectrocardiographyFemaleHumansMaleMiddle Agedcardiac catheterizationscardiovascular diagnostic techniquedeep learninghemodynamic monitoringwearable electronic devices

Identifiers

PMID41038524
PMCPMC12821336

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.