ReviewJournal of advanced research2026
Helicobacter pylori-derived outer membrane vesicles: Pathogenic roles, microbiota interactions, and biomedical applications.
Review in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Bacterial Membrane Vesicles: Biogenesis, Functions, and Emerging Biotechnological Applications.Microorganisms · 2026Review
- Research Status and Prospects ofGastroenterology research and practice · 2026Review
- Beyond acid suppression: the multifaceted role of proton pump inhibitors inFrontiers in microbiology · 2026Review
- Listening to the Past, Shaping the Future: A Data-mining Based and Visual Analysis of Five Decades of Gastric Carcinogenesis Research.Biological procedures online · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHelicobacter pylori (Hp) is a gram-negative, microaerophilic bacterium that infects approximate 45% of the global population. It is a key contributor to chronic gastritis, peptic ulcers, and gastric cancer. Among its secreted products, Hp-derived outer membrane vesicles (Hp-OMVs) are nanoscale proteoliposomal structures that play crucial roles in host-pathogen interactions. AIM OF REVIEW: This review aims to synthesize current knowledge on the formation, composition, and biological functions of Hp-OMVs, with a particular focus on their systemic effects and potential biomedical applications. KEY SCIENTIFIC CONCEPTS OF REVIEW: Hp-OMVs are enriched with virulence-associated proteins and lipids, acting as multifunctional vehicles that facilitate the delivery of toxins, modulation of host immunity, and reshaping of gastrointestinal and oral microbial communities. Emerging preclinical studies suggest that Hp-OMVs may translocate across epithelial barriers and reach distant organs, including the brain, where they have been shown to exacerbate neuroinflammatory responses in murine models of Alzheimer's disease. However, no causal relationship has been demonstrated in humans. More research is urgently needed to confirm such extragastrointestinal connections. In parallel, Hp-OMVs are being explored as versatile platforms for vaccine development, mucosal adjuvants, anti-adhesion therapies, and targeted drug delivery systems, owing to their intrinsic immunogenicity and tissue tropism.
conclusionHp-OMVs represent a unique vesicular modality in Hp pathogenesis with broad biomedical potential. Future research employing multi-omics, single-vesicle analytics, and clinical validation is needed to define their mechanistic roles and translational value.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.