ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2026
In Vivo Positron Emission Tomography Imaging of Presynaptic Density Reveals Stress-Associated Synaptic Deficits Related to Behavioral and Molecular Alterations in Rats.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundPreclinical research indicates that chronic stress can induce synaptic loss in corticolimbic brain regions regulating mood and cognition. Presynaptic density can now be measured in vivo using radioligands targeting synaptic vesicle protein 2A (SV2A) and positron emission tomography (PET). We conducted the first in vivo PET study to investigate chronic stress-induced synaptic density changes in rats and examined correlates with behavior and protein expression.
methodsMale and female Long Evans rats were exposed to chronic unpredictable stress (CUS) (n = 24/sex) and compared with controls (n = 12/sex). Sucrose preference and novel object recognition (NOR) were used to assess stress-related behavioral phenotypes. PET with [
resultsSynaptic density was lower in the PFC of CUS rats relative to controls (d = 0.94, p = .012) and correlated with sucrose preference (r = 0.35, p = .042). Synaptic density was also lower in the hippocampus (d = 0.55, p = .017), which correlated with NOR (r = 0.35 p = .045). Differentially expressed proteins were enriched for transcriptional regulation and metabolic pathways. Proteins implicated in synaptogenesis and neurodegeneration were positively and negatively correlated, respectively, with synaptic density.
conclusionsWe demonstrated that [
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.