Evidence map›Paper›PMID 41037769›Full record

Trial reportJMIR formative research2025

Internet-Delivered Psychological Treatment for Parents With Health Anxiety by Proxy: Replicated Randomized Single-Case Experimental Design.

Katrine Ingeman, Ditte Hoffmann Frydendal, Lisbeth Frostholm, Ellen Bjerre-Nielsen, Kaare Bro Wellnitz, Patrick Onghena, Kristi Wright, Charlotte Ulrikka Rask

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in JMIR formative research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Katrine IngemanDepartment of Child and Adolescent Psychiatry, Research Unit, Aarhus University Hospital Psychiatry, Palle Juul-Jensens Boulevard 175, Aarhus, 8200, Denmark, 45 20542556.ORCID 0000-0001-8146-7769
Ditte Hoffmann FrydendalDepartment of Functional Disorders, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0001-8549-4115
Lisbeth FrostholmDepartment of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark.ORCID 0000-0002-9683-7416
Ellen Bjerre-NielsenDepartment of Child and Adolescent Psychiatry, Research Unit, Aarhus University Hospital Psychiatry, Palle Juul-Jensens Boulevard 175, Aarhus, 8200, Denmark, 45 20542556.ORCID 0009-0009-9124-3027
Kaare Bro WellnitzDepartment of Functional Disorders, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0001-5882-5118
Patrick OnghenaFaculty of Psychology and Educational Sciences, KU Leuven, Leuven, Belgium.ORCID 0000-0002-3986-8312
Kristi WrightDepartment of Psychology, Faculty of Arts, University of Regina, Regina, SK, Canada.ORCID 0000-0002-8858-3452
Charlotte Ulrikka RaskDepartment of Child and Adolescent Psychiatry, Research Unit, Aarhus University Hospital Psychiatry, Palle Juul-Jensens Boulevard 175, Aarhus, 8200, Denmark, 45 20542556.ORCID 0000-0002-7426-0353

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Health anxiety by proxy is characterized by ruminations about severe illness in one's child that can cause severe distress in affected parents. Health anxiety by proxy may lead to repeated unnecessary medical consultations and checking the child's body for symptoms, as well as heightened attention to their child's behavior, sign of illness, and bodily symptoms. It has been hypothesized that health anxiety by proxy may pose a risk for transmission of maladaptive symptom coping and health anxiety from the parent to their child. In spite of this, no targeted treatment has previously been evaluated. Therefore, we developed an internet-delivered psychological treatment containing 8 modules based on cognitive behavioral therapy and acceptance and commitment therapy. Objective: The objective of this study was to investigate the feasibility and effect of the internet-delivered treatment PROXY for parents with health anxiety by proxy. Methods: A total of 4 participants with health anxiety by proxy entered a replicated randomized single-case experimental design. They were randomly allocated to a baseline period of 7-26 days before entering the 8-week treatment and 14-33 days follow-up phase. The primary outcomes were daily measures of anxiety, impact of anxiety, and value-based actions measured using 5 questions answered on a scale of 1-10 through a text-message link. The primary outcomes were analyzed using visual analysis and supplemented with statistical randomization tests. Secondary outcomes were standardized questionnaire measures of anxiety-related symptoms, experience of the treatment, and negative effects of the treatment reported using descriptive statistics for each participant individually. Results: Visual and statistical analyses indicated that PROXY was an effective treatment for 2 participants as the primary outcomes changed in the preferable direction for both of them. The effect of PROXY was questionable for the remaining 2 participants, although visual analysis showed that the impact of anxiety decreased for one of them. The 2 participants with questionable effect also thought that the treatment was too short. All 4 participants were happy with the treatment, but 2 participants experienced that health anxiety for their own health deteriorated during treatment. Conclusions: PROXY holds potential as a treatment for HA by proxy. However, more work is required to determine when and how PROXY should be introduced to parents with HA by proxy, particularly in relation to duration of treatment, possible comorbidities, and the need for findings to be replicated in larger groups.

Indexed as

Acceptance and Commitment TherapyAnxietyCognitive Behavioral TherapyInternet-Based InterventionParentsProxyAdultChildFemaleHumansInternetMaleTreatment Outcomeanxietyanxiety-related symptomschilddepressiondistressfeasibilityhealth anxietyhealth anxiety by proxyillness anxietyinternetinternet-deliveredinternet-delivered treatmentmental healthparental worriesparentsproxypsychologicalpsychological treatmentsevere distresssevere illnesssingle-case experimental designtreatmentyouth

Identifiers

PMID41037769
PMCPMC12490778

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.