ArticleProceedings of the National Academy of Sciences of the United States of America2025
Geometrical compartmentalization of trigger waves.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Microglia-mediated synaptic pruning in neural circuit remodeling: multidimensional control in homeostasis and neuropathology.BMC medicine · 2026Review
- Geometrical compartmentalization of trigger waves.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
Trigger waves, self-regenerating fronts of biochemical activity that spread without losing speed or amplitude, are widespread in cell signaling. Apoptosis is one example of a process that propagates through the cytoplasm via trigger waves. Curiously, in some contexts, like synaptic pruning, apoptotic caspase activation is confined to specific subcellular regions. We hypothesized that at junctions between a thin cytoplasmic extension, like a dendritic spine, and a thicker one, like a dendrite, trigger wave propagation may be blocked even though diffusion is not, as a result of the general properties of trigger waves and bistable systems. This hypothesis was explored theoretically through modeling studies and dimensional arguments, which confirmed that trigger wave compartmentalization was possible and that the critical channel width required for compartmentalization was likely to be biologically relevant. These predictions were then tested experimentally with undiluted
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Registered trials
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