ArticleeLife2025
Lipid peroxidation and type I interferon coupling fuels pathogenic macrophage activation causing tuberculosis susceptibility.
Abstract read
In one paragraph
Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Host-pathogen interactions in tuberculosis: from immunological mechanisms to translational applications.Cell insight · 2026Review
- Skin Carotenoid Scores Reflect Immune Status among Children Living with HIV in Tanzania.The American journal of tropical medicine and hygiene · 2026Article
- Restricted MHC-II trafficking inbioRxiv : the preprint server for biology · 2026Article
- IFN𝛾 and IFN𝛾 mimetics prevent IFN-I-mediated TB susceptibility by regulating iron metabolism and lipid peroxidation.bioRxiv : the preprint server for biology · 2026Article
- Modulation of Ferroptosis During EarlybioRxiv : the preprint server for biology · 2026Article
- Elimination of senescent cells with senolytic drugs as adjunctive host-directed therapy reduces tuberculosis progression in mice.Nature communications · 2026Article
- c-Myc Inhibits Macrophage Antimycobacterial Response in Mycobacterium tuberculosis Infection.The Journal of infectious diseases · 2025Article
- Protocol for developing a mouse model of post-primary pulmonary tuberculosis after hematogenous spread in native lungs and lung implants.STAR protocols · 2025Article
- c-Myc inhibits macrophage antimycobacterial response inbioRxiv : the preprint server for biology · 2025Article
Corrections and comments
- Update of
Authors and funding
19 authors.
Shivraj M YabajiThe National Emerging Infectious Diseases Laboratory, Boston University, Boston, United States.ORCID https://orcid.org/0000-0002-5793-1661
Vadim ZhernovkovSystems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland.ORCID https://orcid.org/0000-0001-8903-1142
Prasanna Babu AravetiThe National Emerging Infectious Diseases Laboratory, Boston University, Boston, United States.ORCID https://orcid.org/0000-0002-5441-3826
Suruchi LataThe National Emerging Infectious Diseases Laboratory, Boston University, Boston, United States.ORCID https://orcid.org/0000-0001-5548-9315
Oleksii S RukhlenkoSystems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland.ORCID https://orcid.org/0000-0003-1863-4987
Salam Al AbdullatifDepartment of Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, United States.
Arthur VanvalkenburgRutgers University, New Jersey Medical School, Center for Data Science, New Brunswick, United States.ORCID https://orcid.org/0009-0007-1793-9160
Yuriy O AlekseyevThe Department of Pathology and Laboratory Medicine, Boston University Chobanian Avedisian School of Medicine, Boston, United States.ORCID https://orcid.org/0000-0001-6105-8861
Qicheng MaDepartment of Biochemistry, and Cell Biology and Genome Science Institute, Boston University Chobanian and Avedisian School of Medicine, Boston, United States.
Gargi DayamaDepartment of Biochemistry, and Cell Biology and Genome Science Institute, Boston University Chobanian and Avedisian School of Medicine, Boston, United States.
Nelson C LauThe National Emerging Infectious Diseases Laboratory, Boston University, Boston, United States.ORCID https://orcid.org/0000-0001-9907-1404
W Evan JohnsonRutgers University, New Jersey Medical School, Center for Data Science, New Brunswick, United States.ORCID https://orcid.org/0000-0002-6247-6595
William R BishaiCenter for TB Research, Johns Hopkins School of Medicine, Baltimore, United States.ORCID https://orcid.org/0000-0002-8734-4118
Nicholas A CrosslandThe National Emerging Infectious Diseases Laboratory, Boston University, Boston, United States.ORCID https://orcid.org/0000-0003-3873-9188
Joshua D CampbellDepartment of Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, United States.ORCID https://orcid.org/0000-0003-0780-8662
Boris N KholodenkoSystems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland.ORCID https://orcid.org/0000-0002-9483-4975
Alexander A GimelbrantAltius Institute for Biomedical Sciences, Seattle, United States.ORCID https://orcid.org/0000-0001-6986-0285
Lester KobzikCellecta, Inc., Mountain View, United States.ORCID https://orcid.org/0000-0003-4328-937X
Igor KramnikThe National Emerging Infectious Diseases Laboratory, Boston University, Boston, United States.ORCID https://orcid.org/0000-0001-6511-9246
Funding
Necrosis in pulmonary TB granulomas: dynamics, mechanisms, therapiesR01HL126066 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KRAMNIK, IGOR, NIEDERWEIS, MICHAEL · 2016 to 2025
$5.6MMechanism and function of autosomal analog of X inactivationR01GM114864 · NIGMS · DANA-FARBER CANCER INST · PI GIMELBRANT, ALEXANDER · 2014 to 2018
$4.9MMultiscale Modeling to Optimize Inhibition of Oncogenic ERK Pathway SignalingR01CA244660 · NCI · YALE UNIVERSITY · PI HLAVACEK, WILLIAM S, KHOLODENKO, BORIS N · 2020 to 2024
$3.4MAberrant immune activation in the tuberculosis granuloma: a pivotal role in necrosisR01HL133190 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BISHAI, WILLIAM RAMSES, KRAMNIK, IGOR · 2016 to 2019
$3.0MRemoving batch effects in high-throughput biomedical studiesR01GM127430 · NIGMS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI William Evan Johnson · 2018 to 2026
$2.4MTransposon landscapes and transcriptome diversity in aging neuronsR01AG052465 · NIA · BRANDEIS UNIVERSITY · PI LAU, NELSON C · 2016 to 2020
$2.0MThe interplay between transposons and piRNA pathways.R01GM135215 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI LAU, NELSON C · 2020 to 2023
$1.8MIntegrative clustering of cells and samples using multi-modal single-cell dataR01LM013154 · NLM · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CAMPBELL, JOSHUA D, YAJIMA, MASANAO · 2019 to 2021
$1.1MVectra Polaris Quantitative Pathology Imaging SystemS10OD030269 · OD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CROSSLAND, NICHOLAS ALEXANDER · 2021 to 2021
$402kVentana Discovery Ultra Research Autostainer: an Ex+ Core serviceS10OD026983 · OD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CROSSLAND, NICHOLAS ALEXANDER · 2019 to 2019
$207kBoston University S10OD026983Boston University S10OD030269Health Research Board, Ireland EPPerMed-2024-1Health Research Board, Ireland ERATRANSCAN-2022-001Horizon Europe 10.3030/101136926National Heart Lung and Blood Institute R01HL126066National Heart Lung and Blood Institute R01HL133190NCI NIH HHS R01 CA244660NCI NIH HHS R01CA244660NHLBI NIH HHS R01 HL126066NHLBI NIH HHS R01 HL133190NIA NIH HHS R01 AG052465NIA NIH HHS R01-AG052465NIGMS NIH HHS R01: 5R01GM127430-07NIGMS NIH HHS R01 GM114864NIGMS NIH HHS R01GM114864NIGMS NIH HHS R01 GM127430NIGMS NIH HHS R01 GM135215NIGMS NIH HHS R01-GM135215NIH HHS S10 OD026983NIH HHS S10 OD030269NLM NIH HHS R01 LM013154NLM NIH HHS R01LM013154
Abstract
A quarter of the human population is infected with
Indexed as
Interferon Type ILipid PeroxidationMacrophage ActivationMacrophagesMycobacterium tuberculosisTuberculosisTuberculosis, PulmonaryAnimalsDisease Models, AnimalDisease SusceptibilityGranulomaHumansMiceMice, Inbred C57BLInterferon Type Iantioxidant defenseimmunologyinfectious diseaseinflammationlipid peroxidationmacrophagemicrobiologymouseMyctuberculosisType I interferon
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.