Evidence map›Paper›PMID 41037262›Full record

ArticleACS applied materials & interfaces2025

Polypept(o)ide Based Biodegradable Cylindrical Polymer Brushes: Controlling Size, Shape, Surface Functionality, and Stability.

Christine Ilona Seidl, Bonan Zhao, Xinye Gao, Rüdiger Berger, Lin Jian, Kaloian Koynov, Meike Gangluff, Rivka Fontijn, Lu Su, Jeroen Bussmann and 2 more

Abstract read
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In one paragraph

Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Christine Ilona SeidlLeiden Academic Center for Drug Research (LACDR), Leiden University, Einsteinweg 55, Leiden 2333CC, The Netherlands.
Bonan ZhaoLeiden Academic Center for Drug Research (LACDR), Leiden University, Einsteinweg 55, Leiden 2333CC, The Netherlands.
Xinye GaoLeiden Academic Center for Drug Research (LACDR), Leiden University, Einsteinweg 55, Leiden 2333CC, The Netherlands.
Rüdiger BergerPhysics at Interfaces, Max Planck Institute for Polymer Research, Ackermannweg 10, Mainz 55128, Germany.ORCID 0000-0002-4084-0675
Lin JianPhysics at Interfaces, Max Planck Institute for Polymer Research, Ackermannweg 10, Mainz 55128, Germany.
Kaloian KoynovPhysics at Interfaces, Max Planck Institute for Polymer Research, Ackermannweg 10, Mainz 55128, Germany.ORCID 0000-0002-4062-8834
Meike GangluffDepartment Chemie, Johannes Gutenberg University Mainz, Duesbergweg 10-14, Mainz 55131, Germany.
Rivka FontijnLeiden Academic Center for Drug Research (LACDR), Leiden University, Einsteinweg 55, Leiden 2333CC, The Netherlands.
Lu SuLeiden Academic Center for Drug Research (LACDR), Leiden University, Einsteinweg 55, Leiden 2333CC, The Netherlands.ORCID 0000-0001-8207-756X
Jeroen BussmannLeiden Academic Center for Drug Research (LACDR), Leiden University, Einsteinweg 55, Leiden 2333CC, The Netherlands.ORCID 0000-0003-2814-3305
Heyang ZhangLeiden Academic Center for Drug Research (LACDR), Leiden University, Einsteinweg 55, Leiden 2333CC, The Netherlands.
Matthias BarzLeiden Academic Center for Drug Research (LACDR), Leiden University, Einsteinweg 55, Leiden 2333CC, The Netherlands.ORCID 0000-0002-1749-9034

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cylindrical polymer brushes (CPBs) enable remarkable control over nanoparticle properties solely through sequential polymerization. The spatial dimensions and functionality of the resulting polymeric nanoparticles can be adjusted by the ratio of backbone to side chain length and the chemical nature of both parts. In this work, we present a convenient and straightforward synthetic pathway to polypept(o)ide-based CPBs using a "grafting-from" strategy utilizing poly-l-lysine (pLys) as the macroinitiator backbone and polysarcosine (pSar) as the side chain. End-capping of pSar chains with azido-butyric acid pentafluorophenyl ester enables facile surface functionalization by click chemistry (e.g., dye labeling). This strategy allows for straightforward control over nanoparticle size (

Indexed as

NanoparticlesPeptidesPolylysinePolymersSarcosineAnimalsClick ChemistryParticle SizeSurface PropertiesZebrafishPeptidesPolylysinePolymerspolysarcosineSarcosinecontrollable size and shapecylindrical polymer brushespolypept(o)ide“stealth-like” effectsurface functionalitythermal stability

Identifiers

PMID41037262
PMCPMC12635966

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.