Evidence map›Paper›PMID 41037233›Full record

ArticleBreast cancer (Tokyo, Japan)2026

Characterization of gut microbiota dysbiosis in breast cancer patients.

Mai Yamada, Makoto Kubo, Kazuhisa Kaneshiro, Masaya Kai, Takafumi Morisaki, Saori Hayashi, Yurina Ochiai, Yo Sato, Kimihisa Mizoguchi, Yuka Takao and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Breast cancer (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mai YamadaDepartment of Surgery and Oncology Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-Ku, Fukuoka, 812-8582, Japan. mai.yk523@kyudai.jp.ORCID http://orcid.org/0009-0005-9482-4063
Makoto KuboDepartment of Surgery and Oncology Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-Ku, Fukuoka, 812-8582, Japan.
Kazuhisa KaneshiroDepartment of Surgery and Oncology Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-Ku, Fukuoka, 812-8582, Japan.
Masaya KaiDepartment of Surgery and Oncology Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-Ku, Fukuoka, 812-8582, Japan.
Takafumi MorisakiDepartment of Breast Surgical Oncology, Kyushu University Hospital, Fukuoka, Japan.
Saori HayashiDepartment of Breast Surgical Oncology, Kyushu University Hospital, Fukuoka, Japan.
Yurina OchiaiDepartment of Breast Surgical Oncology, Kyushu University Hospital, Fukuoka, Japan.
Yo SatoDepartment of Surgery and Oncology Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-Ku, Fukuoka, 812-8582, Japan.
Kimihisa MizoguchiDepartment of Surgery and Oncology Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-Ku, Fukuoka, 812-8582, Japan.
Yuka TakaoDepartment of Surgery and Oncology Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-Ku, Fukuoka, 812-8582, Japan.
Akiko ArimuraDepartment of Surgery and Oncology Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-Ku, Fukuoka, 812-8582, Japan.
Masafumi NakamuraDepartment of Surgery and Oncology Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-Ku, Fukuoka, 812-8582, Japan.

Funding

Japan Society for the Promotion of Science JP21K19532
6 · The paper itself

Abstract

backgroundWhile lifestyle factors are known to be associated with breast cancer development, the potential role of the gut microbiome, which is influenced by lifestyle, as a risk factor is not well understood. We conducted a comparative analysis of the intestinal microbiota between healthy individuals and breast cancer patients to investigate the potential impact of gut microbiome composition on breast cancer development. This study aimed to explore the role of intestinal microbial communities in breast cancer pathogenesis.

methodsWe conducted a comparative analysis of fecal 16S rRNA amplicon sequencing data from 100 individuals in the general population and 79 breast cancer patients. We investigated the differences between the two groups in terms of relative abundance, absolute quantity, diversity, and functionality of the gut microbiota.

resultsBreast cancer groups showed higher levels of Firmicutes and lower levels of Bacteroidota at the phylum level, and an increase in Fusobacteriota was found in the human epidermal growth factor receptor 2 (HER2)-negative breast cancer group. Additionally, certain genera were more or less common in breast cancer groups at the genus level. The study also indicated lower gut microbiota diversity and loss of heterogeneity in breast cancer groups and reduced functional genes and pathways.

conclusionCompared to the general population, breast cancer patients exhibited a distinct dysbiosis in their gut microbiota. Further investigation is warranted to determine if this dysbiotic state, linked to a predicted downregulation of functional pathways critical for homeostasis, plays a role in breast cancer development.

Indexed as

Breast NeoplasmsDysbiosisGastrointestinal MicrobiomeAdultAgedBacteriaCase-Control StudiesFecesFemaleHumansMiddle AgedRNA, Ribosomal, 16SRNA, Ribosomal, 16SBreast cancerDysbiosisGut microbiomeLifestyle factorRNA sequencing

Identifiers

PMID41037233
PMCPMC12789142

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.