Evidence map›Paper›PMID 41037194›Full record

ReviewDrugs2025

The Current Treatment Landscape for Congenital Adrenal Hyperplasia.

Joseph J Tonge, Irina Bacila, Nils P Krone

Abstract readReview
PubMed Publisher
In one paragraph

Review in Drugs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Joseph J TongeDivision of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Beech Hill Rd, Sheffield, S10 2RX, UK.ORCID http://orcid.org/0000-0002-7492-8288
Irina BacilaDivision of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Beech Hill Rd, Sheffield, S10 2RX, UK.ORCID http://orcid.org/0000-0001-7726-4299
Nils P KroneDivision of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Beech Hill Rd, Sheffield, S10 2RX, UK. n.krone@sheffield.ac.uk.ORCID http://orcid.org/0000-0002-3402-4727

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive endocrine disorders caused by impaired steroidogenesis and insufficient cortisol production from the adrenal cortex. The most common form of CAH is 21-hydroxylase deficiency, caused by mutations in the CYP21A2 gene. This enzyme deficiency causes failure to progress through the steroidogenic pathways, consequently there is an increased synthesis of steroid hormone precursors that result in adrenal androgens excess, leading to virilisation in female patients. Over the past two decades, significant progress has been made in optimising corticosteroid replacement strategies, with a focus on reducing androgen excess while minimising glucocorticoid exposure. Modified-release hydrocortisone formulations, such as Efmody

Indexed as

Adrenal Hyperplasia, CongenitalGlucocorticoidsFemaleHormone Replacement TherapyHumansHydrocortisoneSteroid 21-HydroxylaseGlucocorticoidsHydrocortisoneSteroid 21-Hydroxylase

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.