Evidence map›Paper›PMID 41037138›Full record

ArticleDiscover oncology2025

Expression of FoxP3 in oral squamous cell carcinoma and its biological significance.

Lina Jiang, Yangxiao Zhang, Chenchen Zhu, Luwen Song, Zhenghao Ma, Hongsheng Liu, Zhenxing Su, Mingxun Xia, Jiancheng Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lina JiangSchool of Stomatology, Bengbu Medical University, No. 2600 Donghai Road, Bengbu, 233030, China. jln_baby@163.com.
Yangxiao ZhangThe First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Chenchen ZhuThe First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Luwen SongSchool of Stomatology, Bengbu Medical University, No. 2600 Donghai Road, Bengbu, 233030, China.
Zhenghao MaSchool of Stomatology, Bengbu Medical University, No. 2600 Donghai Road, Bengbu, 233030, China.
Hongsheng LiuSchool of Stomatology, Bengbu Medical University, No. 2600 Donghai Road, Bengbu, 233030, China.
Zhenxing SuSchool of Basic Medicine, Bengbu Medical University, Bengbu, China.
Mingxun XiaSchool of Stomatology, Bengbu Medical University, No. 2600 Donghai Road, Bengbu, 233030, China.
Jiancheng LiThe First Affiliated Hospital of Bengbu Medical University, Bengbu, China.

Funding

Bengbu Science and Technology innovation guidance project 2024ZD0003Key Special Projects in Translational Medicine of Bengbu Medical College BYTM 2019005the University Cooperative Research and Public Health Collaborative Innovation Project of Anhui Province GXXT-2020-021
6 · The paper itself

Abstract

INTRODUCTION AND

objectiveOral squamous cell carcinoma (OSCC) is a highly malignant tumor that is prone to lymph node metastasis and distant metastasis. FoxP3 is a specific surface marker of regulatory T cells, and its role in various tumors has been confirmed, which is related to tumor progression and prognosis. However, there are relatively few studies on FoxP3 in OSCC, and the role of FoxP3 in OSCC remains unclear. MATERIALS AND

methodsIn this study, the expression of FoxP3 in OSCC was analyzed using data from the TCGA public database. Additionally, 78 OSCC patient samples were analyzed using immunohistochemistry to evaluate the role of FoxP3 in the prognosis of OSCC. The data from TCGA were then investigated using GSEA to explore possible carcinogenic mechanisms. Finally, the online analysis website TIMER was used to analyze the relationship between FoxP3 expression and tumor-associated immune cells.

resultsThe expression of FoxP3 was up-regulated in OSCC tumor tissues, and the expression level was related to the stage of OSCC. The high expression of FoxP3 was associated with better overall survival. FoxP3 expression was positively correlated with the infiltration level of CD4

conclusionsFoxP3 plays an important role in the progression of OSCC and may be related to the prognosis of the tumor.

Indexed as

Biological significanceDifferences in expressionFoxP3Oral squamous cell carcinoma

Identifiers

PMID41037138
PMCPMC12491139

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.