Evidence map›Paper›PMID 41037128›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

β-sitosterol attenuates hepatic lipid accumulation and fibrosis via NLRP3 signaling in MASH mice.

Xuan Wang, Kaixia Wang, Wenlan Gao, Zhenxiu Liu, Jiaojiao Zhou, Feng Tao, Yi Chen

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Frontiers in pharmacology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xuan Wang *Endocrinology Department, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200071, China.
Kaixia Wang *Department of Infection, Oriental Hospital Affiliated to Tongji University, Shanghai, 200120, China.
Wenlan Gao *Endocrinology Department, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200071, China.
Zhenxiu LiuEndocrinology Department, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200071, China.
Jiaojiao ZhouEndocrinology Department, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200071, China.
Feng TaoEndocrinology Department, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200071, China. taofeng@shutcm.edu.cn.
Yi ChenEndocrinology Department, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200071, China. chenyi197831@163.com.

Funding

Shanghai Science and Technology Commission Science and technology innovation action plan 23Y11921500
6 · The paper itself

Abstract

Β-sitosterol (SIT), a natural phytosterol, has not been fully explored for its therapeutic potential in metabolic dysfunction-associated steatohepatitis (MASH). In this study, MASH was induced in mice via a high-fat, high-cholesterol (HFHC) diet, and lipid accumulation in HepG2 cells was triggered with oleic acid (OA), while the role of the NLRP3 inflammasome was explored in NLRP3-knockout (NLRP3

Indexed as

Lipid MetabolismLiverLiver CirrhosisNLR Family, Pyrin Domain-Containing 3 ProteinNon-alcoholic Fatty Liver DiseaseSitosterolsAnimalsDiet, High-FatHep G2 CellsHumansInflammasomesMaleMiceMice, Inbred C57BLMice, KnockoutSignal Transductiongamma-sitosterolInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseSitosterolsFibrosisInflammasomeNLRP3Nonalcoholic steatohepatitisβ-sitosterol

Identifiers

PMID41037128

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.