Evidence map›Paper›PMID 41037120›Full record

ArticleInflammopharmacology2025

Diallyl disulfide attenuates DSS-induced colonic fibrosis in mice by modulating gut microbiota and Nrf2 signaling.

Shuangshuang Hai, Yan Chen, Meiyan Zhang, Weixin Liu, Xiaohong Sun

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In one paragraph

Article in Inflammopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shuangshuang Hai *Department of Geriatrics, The Fourth Affiliated Hospital of China Medical University, Shenyang, 110032, Liaoning, China.
Yan Chen *Department of Geriatrics, The Fourth Affiliated Hospital of China Medical University, Shenyang, 110032, Liaoning, China.
Meiyan Zhang *Department of Geriatrics, The Fourth Affiliated Hospital of China Medical University, Shenyang, 110032, Liaoning, China.
Weixin LiuDepartment of Gastroenterology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, Liaoning, China. weixinliu6558@163.com.ORCID http://orcid.org/0009-0007-0501-8866
Xiaohong SunDepartment of Geriatrics, The Fourth Affiliated Hospital of China Medical University, Shenyang, 110032, Liaoning, China. xhsun@cmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe use of natural medicines as adjuvant therapies for fibrotic diseases has recently garnered significant attention. Diallyl disulfide (DADS), a bioactive sulfur compound from garlic, exhibits antioxidant, anti-inflammatory, and immunomodulatory effects, but its impact on colitis-associated intestinal fibrosis is unknown.

methodsWe administered DADS (80 mg/kg orally) to mice with dextran sulfate sodium (DSS)-induced chronic colitis-associated intestinal fibrosis and assessed clinical parameters, histopathological, immunohistochemistry, 16S rDNA-based gut microbiota profiling, and Mendelian randomization analysis.

resultsDADS treatment ameliorated weight loss, disease activity index (DAI), colon shortening and histological damage, and reduced inflammatory infiltration and collagen deposition. Mechanistically, DADS activated the Nrf2 antioxidant pathway, inhibited TGF-β1/Smad3 fibrogenic signaling, and favorably altered gut microbial diversity and composition.

conclusionBy engaging Nrf2, suppressing TGF-β1/Smad3 and modulating the gut microbiota, DADS attenuates colitis-associated intestinal fibrosis, highlight its potential as novel anti-fibrotic adjuvant.

Indexed as

Allyl CompoundsColitisDisulfidesGastrointestinal MicrobiomeNF-E2-Related Factor 2AnimalsAntioxidantsColonDextran SulfateDisease Models, AnimalFibrosisMaleMiceMice, Inbred C57BLSignal TransductionSmad3 ProteinAllyl CompoundsAntioxidantsDextran Sulfatediallyl disulfideDisulfidesNfe2l2 protein, mouseNF-E2-Related Factor 2Smad3 ProteinTransforming Growth Factor beta1ColitisDiallyl disulfideGut microbiotaIntestinal fibrosisNrf2

Identifiers

PMID41037120

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.