Acquired Gray platelet syndrome as a rare hematologic complication in a case of JAK2-positive post polycythemia Vera myelofibrosis.

Aishwarya Pradeep, Ayo S Falade, Juliana Perez Botero, Dong C Chen, Rajiv K Pruthi, Aasiya Matin

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Article in Annals of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Aishwarya PradeepDepartment of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, USA. pradeep.aishwarya@mayo.edu.ORCID http://orcid.org/0000-0002-0641-2861

Ayo S FaladeDivision of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.

Juliana Perez BoteroDivision of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

Dong C ChenDivision of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

Rajiv K PruthiDivision of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.

Aasiya MatinDivision of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the case of a 70-year-old male with a history of JAK2 mutation-positive post-polycythemia vera myelofibrosis and an acquired bleeding disorder. Investigations revealed platelet dysfunction, and platelet electron microscopy demonstrated an acquired gray platelet syndrome. His platelet function improved with desmopressin administration, and he successfully underwent a central venous catheter placement and hematopoietic stem cell transplant with no bleeding complications. Follow up testing demonstrated normalization of platelet function testing and resolution of his acquired gray platelet syndrome.

Indexed as

Gray Platelet SyndromeJanus Kinase 2Polycythemia VeraPrimary MyelofibrosisAgedBlood PlateletsHematopoietic Stem Cell TransplantationHumansMaleJAK2 protein, humanJanus Kinase 2Acquired gray platelet syndromeBleeding disorderCase reportHematopoietic stem cell transplantPlatelet dysfunction

Identifiers

PMID41037102

DOI10.1007/s00277-025-06587-5

PMCPMC12764662

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