Evidence map›Paper›PMID 41037050›Full record

ReviewMayo Clinic proceedings2025

Individualized Medicine in the Era of Artificial Intelligence.

Konstantinos N Lazaridis, Eric W Klee, Timothy B Curry, Victor E Ortega, William V Bobo, Arjun P Athreya, Rebekah M Samsonraj

Abstract readReview
In one paragraph

Review in Mayo Clinic proceedings, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Konstantinos N LazaridisCenter for Individualized Medicine, College of Medicine and Science, Mayo Clinic, Rochester, MN; Division of Gastroenterology and Hepatology, College of Medicine and Science, Mayo Clinic, Rochester, MN. Electronic address: Lazaridis.Konstantinos@mayo.edu.
Eric W KleeCenter for Individualized Medicine, College of Medicine and Science, Mayo Clinic, Rochester, MN; Department of Clinical Genomics, College of Medicine and Science, Mayo Clinic, Rochester, MN; Department of Quantitative Health Sciences, College of Medicine and Science, Mayo Clinic, Rochester, MN.
Timothy B CurryCenter for Individualized Medicine, College of Medicine and Science, Mayo Clinic, Rochester, MN; Department of Anesthesiology and Perioperative Medicine, College of Medicine and Science, Mayo Clinic, Rochester, MN.
Victor E OrtegaCenter for Individualized Medicine, College of Medicine and Science, Mayo Clinic, Scottsdale, AZ.
William V BoboDepartment of Psychiatry and Psychology, College of Medicine and Science, Mayo Clinic, Jacksonville, FL.
Arjun P AthreyaDepartment of Molecular Pharmacology and Experimental Therapeutics, College of Medicine and Science, Mayo Clinic, Rochester, MN.
Rebekah M SamsonrajCenter for Individualized Medicine, College of Medicine and Science, Mayo Clinic, Rochester, MN.

Funding

Effects of Rare Variants and Ancestry on Beta Agonist Response in Asthma and COPDR01HL142992 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ORTEGA, VICTOR E. · 2019 to 2023
$3.7M
NHLBI NIH HHS R01 HL142992
6 · The paper itself

Abstract

The goal of individualized medicine is to provide a precise approach for the prevention, diagnosis, and treatment of disease, utilizing information about an individual's genomic, environmental, and lifestyle patterns. The rapid advancements in artificial intelligence (AI) have led to the application of sophisticated approaches including machine learning, generative AI, and large language models that could lead to discoveries and practice implementations aimed at improving clinical decision making and health care delivery through diverse applications. Nevertheless, the exact role of AI in supporting individualized medicine continues to evolve. In this position paper, we present our principles of applying AI to bolster the vision of the Mayo Clinic Center for Individualized Medicine. Leveraging the Center for Individualized Medicine's strategy on innovation and transformation as well as existing state-of-the-art operational architecture and capacity in handling large corpora of data (ie, multiomics, digital, multimodal data), we envision an AI-powered integration of such information toward an enterprise-wide adoption to serve the needs of individualized clinical practice of the future.

Indexed as

Artificial IntelligencePrecision MedicineHumansMachine Learning

Identifiers

PMID41037050
PMCPMC13294813

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.