Evidence map›Paper›PMID 41036866›Full record

Observational studyAntimicrobial agents and chemotherapy2025

Cefazolin population pharmacokinetics in children undergoing maintenance hemodialysis for kidney failure.

Romain Berthaud, Saïk Urien, Saoussen Krid, Frantz Foissac, Mehdi Oualha, Michaël Thy, Olivia Boyer, Agathe Béranger, Déborah Hirt, Sihem Benaboud and 2 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Romain BerthaudUniversité Paris Cité, INSERM, Pharmacologie et Evaluations des Thérapeutiques chez l'Enfant et la Femme Enceinte, Paris, France.ORCID 0000-0003-0165-7947
Saïk UrienUniversité Paris Cité, INSERM, Pharmacologie et Evaluations des Thérapeutiques chez l'Enfant et la Femme Enceinte, Paris, France.
Saoussen KridService de Néphrologie Pédiatrique, AP-HPH, Hôpital Necker-Enfants Malades, Paris, France.
Frantz FoissacUniversité Paris Cité, INSERM, Pharmacologie et Evaluations des Thérapeutiques chez l'Enfant et la Femme Enceinte, Paris, France.
Mehdi OualhaUniversité Paris Cité, INSERM, Pharmacologie et Evaluations des Thérapeutiques chez l'Enfant et la Femme Enceinte, Paris, France.
Michaël ThyUniversité Paris Cité, INSERM, Pharmacologie et Evaluations des Thérapeutiques chez l'Enfant et la Femme Enceinte, Paris, France.
Olivia BoyerService de Néphrologie Pédiatrique, AP-HPH, Hôpital Necker-Enfants Malades, Paris, France.
Agathe BérangerUniversité Paris Cité, INSERM, Pharmacologie et Evaluations des Thérapeutiques chez l'Enfant et la Femme Enceinte, Paris, France.
Déborah HirtUniversité Paris Cité, INSERM, Pharmacologie et Evaluations des Thérapeutiques chez l'Enfant et la Femme Enceinte, Paris, France.ORCID 0000-0002-9898-2609
Sihem BenaboudUniversité Paris Cité, INSERM, Pharmacologie et Evaluations des Thérapeutiques chez l'Enfant et la Femme Enceinte, Paris, France.
Jean-Marc TréluyerUniversité Paris Cité, INSERM, Pharmacologie et Evaluations des Thérapeutiques chez l'Enfant et la Femme Enceinte, Paris, France.
Naïm BouazzaUniversité Paris Cité, INSERM, Pharmacologie et Evaluations des Thérapeutiques chez l'Enfant et la Femme Enceinte, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to develop a population pharmacokinetic model of cefazolin in children undergoing maintenance hemodialysis for kidney failure and simulate dosing regimens to optimize patients' exposure. Cefazolin plasma concentrations were quantified using high-performance liquid chromatography. A non-linear mixed-effect modeling approach was used to investigate cefazolin pharmacokinetics. Optimal dosing regimens were determined using Monte Carlo simulations targeting 100% of the time a free plasma concentration four times above the minimum inhibitory concentration (MIC) and total plasma concentration less than 80 mg/L (100% fT > 4 × MIC and

Indexed as

Anti-Bacterial AgentsCefazolinRenal DialysisRenal InsufficiencyAdolescentChildChild, PreschoolFemaleHumansInfantMaleMicrobial Sensitivity TestsMonte Carlo MethodAnti-Bacterial AgentsCefazolincefazolinchildrendialysishemodialysiskidney failuremaintenancepopulation pharmacokineticsrenal replacement therapy

Identifiers

PMID41036866
PMCPMC12587577

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.