Evidence map›Paper›PMID 41036846›Full record

ArticlemSphere2025

Antifungal, antibacterial, and anti-inflammatory activity of glycerol dithionomonolaurate, an analog of glycerol monolaurate.

Patrick M Schlievert, Paul E Brennan, Robert E Klem, Dayton T Reardan

Abstract read
In one paragraph

Article in mSphere, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Patrick M SchlievertNiche Biopharmaceuticals, Shorewood, Minnesota, USA.ORCID 0000-0001-8314-9369
Paul E BrennanNuffield Department of Medicine, Centre for Medicines Discovery, University of Oxford, Oxford, United Kingdom.
Robert E KlemNiche Biopharmaceuticals, Shorewood, Minnesota, USA.
Dayton T ReardanNiche Biopharmaceuticals, Shorewood, Minnesota, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glycerol dithionomonolaurate (NB2) is an analog of the natural antimicrobial compound glycerol monolaurate (GML) with enhanced antimicrobial activity. The advantage of NB2 over GML is the presence of a dithionate to greatly reduce microbial cleavage through glycerol ester hydrolases, such as IMPORTANCE: Fungi and many bacteria commonly develop resistance to antimicrobial agents or have inherent resistance. Many microbes initiate infections through the skin and mucous membranes, in part by producing toxins and causing harmful inflammation. We describe a novel topical antimicrobial agent, glycerol dithionomonolaurate (NB2), effective against

Indexed as

Anti-Bacterial AgentsAntifungal AgentsAnti-Inflammatory AgentsLauratesMonoglyceridesAnimalsCandidaGlycerolHumansMicrobial Sensitivity TestsRabbitsStaphylococcus aureusAnti-Bacterial AgentsAntifungal AgentsAnti-Inflammatory AgentsGlycerolLauratesMonoglyceridesmonolaurinanti-inflammatoryantimicrobial agentCandida albicansCandida aurisgram-negative bacteriagram-positive bacteria

Identifiers

PMID41036846
PMCPMC12570472

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.