ReviewCurrent pharmaceutical design2026
Polycaprolactone-Based Nanocomposites for Wound Healing: Progress, Pitfalls, and Prospects.
Review in Current pharmaceutical design, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wound healing is a dynamic and multifactorial biological process involving complex interactions among cells, cytokines, and growth factors. The development of advanced therapeutic dressings has become essential to accelerate healing, prevent infections, and minimize scar formation. Among the various biomaterials investigated, poly(ε-caprolactone) (PCL)-based nanocomposites have attracted significant attention due to their excellent biocompatibility, controllable biodegradability, mechanical strength, and high drugloading efficiency. This review provides a comprehensive overview of the characteristics that make PCL a promising material for wound healing applications and presents an integrated analysis of various PCL-based strategies for delivering therapeutic agents across acute and chronic wound models. It covers multiple fabrication approaches, including electrospinning, nanoparticle incorporation, and surface modification, with a focus on enhancing biological performance and functional outcomes. The review also addresses key limitations associated with PCL systems, such as their inherently slow degradation rate, potential for burst drug release, and challenges related to large-scale manufacturing. Future directions emphasize the development of stimuliresponsive and multifunctional dressings, the blending of PCL with other natural or synthetic polymers, and the application of advanced technologies, such as three-dimensional bioprinting, to create patient-specific solutions. By consolidating findings from a broad spectrum of preclinical and translational studies, this review aims to offer a thorough and current understanding of the biomedical potential of PCL, the existing challenges, and the innovations required for its successful clinical application in wound care.
Indexed as
Identifiers
41036742What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.