ArticleNucleic acids research2025
Iron-sensitive RNA regulation by poly C-binding proteins.
Article in Nucleic acids research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Iron chaperones and RNA-binding proteins, PCBP1 and PCBP2, maintain hepatic iron balance and protect against ferroptosis.Free radical biology & medicine · 2026Article
- Uridine restores oocyte quality and mitigates female reproductive aging by inhibition of ferroptosis in mice.Nature communications · 2026Article
- The Interaction Between Iron and Selenium Affects Ferroptosis in Colorectal Cancer.International journal of molecular sciences · 2026Review
- Reexamining the Role of Amyloid β Clearance from the Brain: Exporting Labile Iron from the Interstitial Fluid Performs a Protective Function.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Iron is essential for normal cellular function. Homeostatic responses to low iron availability have long been known to rely on posttranscriptional mechanisms. Poly C-binding proteins (PCBPs) are essential RNA-binding proteins that regulate alternative splicing (AS), translation, and RNA stability. They also serve as critical iron chaperones that manage intracellular iron flux. However, the impact of cellular iron levels on the PCBP-directed transcriptome has not been globally evaluated. We found broad transcriptome changes, including AS, in response to low iron availability consistent with numerous operant posttranscriptional mechanisms that sense iron. By comparing AS directed by PCBP1 and PCBP2 to the iron-sensitive transcriptome, we found genes with iron-sensitive PCBP-mediated splicing regulation. We also found that iron chelation-induced splicing changes were attenuated with knockdown of PCBPs. Further, we demonstrate that iron chelation or mutation of PCBP1 iron binding residues enhances PCBP1 RNA association. This work highlights widespread iron-sensitive RNA regulation and identifies PCBP1 and PCBP2 as critical splicing factors contributing to this response.
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Registered trials
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