Evidence map›Paper›PMID 41036584›Full record

ArticlePhysiological reports2025

Heat acclimation prevents neurobehavioral and physiological disorders in mice exposed to chronic aircraft noise.

Kangli Zhang, Xiaojing Lin, Ching-Ping Chang, Xueqing Yi, Wei Wu, M J Walker, Qingjian Ding, Kai Liu, Chuanning Sun, Yanping Sun and 3 more

Abstract read
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kangli ZhangThe Guidance Center for Military Psychology of PLA; Key Laboratory of Military Medical Psychology and Stress Biology of PLA; Department of Psychology, The 960th Hospital of Joint Logistics Support Force of PLA, Jinan, Shandong Province, China.
Xiaojing LinThe Guidance Center for Military Psychology of PLA; Key Laboratory of Military Medical Psychology and Stress Biology of PLA; Department of Psychology, The 960th Hospital of Joint Logistics Support Force of PLA, Jinan, Shandong Province, China.
Ching-Ping ChangDepartment of Medical Research, Chi Mei Medical Center, Tainan, Taiwan.ORCID 0000-0003-0890-9414
Xueqing YiThe Guidance Center for Military Psychology of PLA; Key Laboratory of Military Medical Psychology and Stress Biology of PLA; Department of Psychology, The 960th Hospital of Joint Logistics Support Force of PLA, Jinan, Shandong Province, China.
Wei WuDepartment of Neurological Surgery, Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indianan, USA.
M J WalkerDepartment of Neurological Surgery, Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indianan, USA.
Qingjian DingBig Data Analytics Laboratory of Sport Performance Assessment, Sport College of Shandong University, Jinan, Shandong Province, China.
Kai LiuDepartment of Medical Imaging, The 960th Hospital of Joint Logistics Support Force of PLA, Jinan, Shandong Province, China.
Chuanning SunBig Data Analytics Laboratory of Sport Performance Assessment, Sport College of Shandong University, Jinan, Shandong Province, China.
Yanping SunDepartment of Applied Psychology, College of Sports and Health, Shandong Sport University, Jinan, Shandong Province, China.
Zhongya ShiShandong Huayi Biotechnology Co., Ltd, Jinan, Shandong Province, China.
Cheng-Hsien LinDepartment of Medicine (Basic Sciences), Mackay Medical University, New Taipei City, Taiwan.ORCID 0000-0002-8234-4442
Gang SunThe Guidance Center for Military Psychology of PLA; Key Laboratory of Military Medical Psychology and Stress Biology of PLA; Department of Psychology, The 960th Hospital of Joint Logistics Support Force of PLA, Jinan, Shandong Province, China.

Funding

Basic Research Key Program, Defense Advanced Research Projects of PLA 2019-JCJQ-ZNM-02Chi Mei Medical Center CMFHT11401Mackay Medical University (MMU; formerly Mackay Medical College, MMC) 1081A01Mackay Medical University (MMU; formerly Mackay Medical College, MMC) 1081B09The 960th Hospital, Joint Logistics Support Force of PLA 2018ZX03
6 · The paper itself

Abstract

We aimed to test whether heat acclimation (HA) would protect against aircraft noise (AN)-induced neurobehavioral and physiological disorders in mice. A total of 90 adult male mice were equally divided into three groups: control (c) plus non-AN group, c plus AN group, and HA plus AN group. Neurobehavioral performances included passive avoidance tasks (to assess learning and memory function), Y-maze tests (to assess spatial memory ability), and novel object recognition tests. Physiological functions included stress responses, inflammation, and oxidative stress, which were determined biochemically. The severity of endotoxemia was determined by measuring the serum levels of lipopolysaccharide. Both gut barrier and blood-brain barrier permeability were determined by fluorescein isothiocyanate and Evans Blue dye measurement, respectively. Compared to c+non-AN mice, the c+AN mice displayed neurobehavioral disorders along with exacerbated stress reactions, gut barrier disruption, endotoxemia, blood-brain barrier disruption, and hippocampal inflammation and oxidative stress. Compared to c+AN mice, the HA+AN mice had significantly less severity of all the abovementioned behavioral and physiological impairments. These results suggest that HA counteracts neurobehavioral and physiological disorders in mice exposed to aircraft noise.

Indexed as

AcclimatizationAircraftBehavior, AnimalHot TemperatureNoise, TransportationAnimalsBlood-Brain BarrierHippocampusMaleMaze LearningMiceOxidative Stressaircraft noiseblood–brain barrier disruptionendotoxemiagut barrier disruptionheat acclimationhippocampusneurobehavioral disorders

Identifiers

PMID41036584
PMCPMC12489467

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.