ArticleCurrent research in food science2025
Astringent flavanol fires the locus-noradrenergic system, regulating neurobehavior and autonomic nerves.
Article in Current research in food science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Acute pre-exercise oral intake of cacao polyphenols attenuates central fatigue development during sustained low-intensity ankle dorsiflexion exercise in healthy young male adults.Physiological reports · 2026Trial
- C-Ring Structure-Dependent Redox Properties of Flavonoids Regulate the Expression of Bioactivity.Antioxidants (Basel, Switzerland) · 2026Article
- Sensory signaling mediates the systemic metabolic and neurological effects of epigallocatechin gallate.Frontiers in nutrition · 2026Article
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Authors and funding
14 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Astringency is a characteristic exhibited by only a limited number of polyphenolic compounds which show high electrochemical activity and are susceptible to oxidation at neutral pH conditions like the oral cavity and small intestine. Large-scale intervention studies have demonstrated that the astringent flavanol (FLs) can restore hippocampal-dependent memory. However, due to the low bioavailability of FLs, the mechanism of action remains unclear. In this study, we aimed to elucidate the mechanism by which FLs acts on the nervous system through the gastrointestinal tract. Following a single gavage dose of FLs to mice, spontaneous motor activity in the open field and improved short-term memory in the novel object test were enhanced. Concurrently, activation of stress response systems, such as the sympathetic-adrenal-medullary axis (increased urinary catecholamines) and the hypothalamic-pituitary-adrenal axis (increased corticotropin-releasing hormone mRNA in paraventricular nucleus) was also observed. By the Mass imaging and
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