ArticleJournal of toxicology2025
Investigating the Impact of Zinc Oxide Nanoparticles and Folic Acid on Neuronal Markers in a Rat Model of Nanotoxicity.
Article in Journal of toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Ferroptosis-induced immune modulation: a new frontier in glioblastoma therapy.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Zinc Oxide Nanoparticle-Induced Neurotoxicity: Underlying Molecular Mechanisms and Future Perspectives.Toxics · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exposure to zinc oxide nanoparticles (ZnONPs) is more likely due to their wide utilization in the food and pharmaceutical sectors. Therefore, serum neuromarkers and hippocampal tissue were examined for the potential prophylactic impact of folic acid in four groups of rats, each consisting of 10 animals. The first group had 150 mg/kg ZnONPs orally every day for 2 weeks. The second group received 10 mg/kg of folic acid intraperitoneal (ip) for 1 week, followed by ZnONPs daily for 2 weeks. The third group received folic acid only, while the control group was given distilled water. At the end of the experiments, hippocampi were examined, and serum concentrations were measured for glial fibrillary acidic protein (GFAP), myelin basic protein (MBP), monoamine oxidase A (MAOA), and neurofilament light polypeptide (NEFL). ZnONPs-exposed animals exhibited significantly lower levels of GFAP and MBP (
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