ArticleOpen veterinary journal2025
Sedative effects of detomidine and midazolam combination in horses.
Article in Open veterinary journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
10 authors.
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Abstract
Background: The combination of detomidine and midazolam may provide safer sedation with muscle-relaxant effects, which are particularly necessary during standing procedures. Aim: Thus, the objective of this study was to evaluate the sedative and muscle-relaxant effects of the detomidine/midazolam combination in horses through a pharmacodynamic study. Methods: Five horses were used and subjected to four experimental protocols: 15 µg/kg of detomidine (D15); a combination of detomidine (15 µg/kg) with 25 µg/kg (DM25), 50 µg/kg (DM50), or 75 µg/kg (DM75) of midazolam administered intravenously. The sedative and muscle-relaxant effects, as well as physiological parameters, were evaluated and statistically analyzed. Results: All protocols resulted in a decrease in head height, although no significant difference was observed among them. The acoustic stimulus response and tongue tone relaxation showed significant effects in the global analysis. Conclusion: This study contributes to our understanding of the application of this combination in equine sedation protocols.
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