ArticlePediatric discovery2025
Thiostrepton Suppresses the Progression of Rhabdomyosarcoma by Inhibiting the PI3K-AKT Signaling Pathway.
Yu Wang, Peng Hong, Zhiqiang Gao, Wei Ma, Zaihong Hu, Jie Lin, Kongkong Cui, Qinlin Shi, Xiao-Mao Tian, Guanghui Wei
Abstract read
In one paragraphArticle in Pediatric discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Yu WangDepartment of Urology Children's Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Structural Birth Defect and Reconstruction Chongqing China.ORCID https://orcid.org/0000-0003-0931-5810 Peng HongDepartment of Urology Children's Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Structural Birth Defect and Reconstruction Chongqing China.
Zhiqiang GaoDepartment of Urology Children's Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Structural Birth Defect and Reconstruction Chongqing China.
Wei MaDepartment of Urology Children's Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Structural Birth Defect and Reconstruction Chongqing China.
Zaihong HuDepartment of Urology Children's Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Structural Birth Defect and Reconstruction Chongqing China.
Jie LinDepartment of Urology Children's Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Structural Birth Defect and Reconstruction Chongqing China.ORCID https://orcid.org/0009-0000-8260-1675 Kongkong CuiDepartment of Urology Children's Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Structural Birth Defect and Reconstruction Chongqing China.
Qinlin ShiDepartment of Urology Children's Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Structural Birth Defect and Reconstruction Chongqing China.
Xiao-Mao TianDepartment of Urology Children's Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Structural Birth Defect and Reconstruction Chongqing China.
Guanghui WeiDepartment of Urology Children's Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Structural Birth Defect and Reconstruction Chongqing China.ORCID https://orcid.org/0000-0002-7822-8684 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Rhabdomyosarcoma (RMS), the most common pediatric soft tissue sarcoma with 5-year survival below 30% in high-risk/metastatic cases, was investigated through integrated bioinformatics analysis (identifying 269 conserved differentially expressed genes in GEO datasets GSE28511/GSE141690) and experimentally validated thiostrepton (TST), a ribosomal-targeting antibiotic, as a potent therapeutic candidate via Connectivity Map analysis (
Indexed as
childhood neoplasmsPI3K‐AKT signaling pathwayrhabdomyosarcomathiostrepton (TST)
Identifiers
PMID41036313
PMCPMC12483292
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