The predictive role of platelet-to-lymphocyte ratio and systemic immune-inflammation index in young and middle-aged patients with tibial plateau fractures.

Background: There is suggestive evidence that the platelet-to-lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) are related to the severity of fracture. The purpose of this study was to investigate the role of PLR and SII in predicting fracture severity in young and middle-aged patients with tibial plateau fractures (TPFs). Methods: A retrospective cohort study involving 229 patients with isolated TPFs was conducted between January 2015 and December 2019. Medical records of hospitalized patients were extracted from the electronic case system. Three experienced orthopedic surgeons classified the imaging data according to the Schatzker classification. All the patients were divided into two groups: group1 consisted of fractures of mild to moderate severity (Schatzker types I-IV), and group2 consisted of fractures of severe severity (Schatzker types V-VI). Platelet, neutrophil, and lymphocyte values at admission were obtained. The PLR = platelet/lymphocyte counts and the SII = platelet × neutrophil/lymphocyte counts were noted. Patients in groups 1 and 2 were statistically compared in terms of PLR and SII value on hospital admission. Results: There were significant differences in the blood PLR, SII, Na Conclusions: The PLR and SII are simple and economical biomarkers that require only routine blood tests with low associated costs. They can be calculated directly from platelet, neutrophil, and lymphocyte counts in standard blood routine reports, making them readily accessible and cost-effective tools to predict the severity of tibial plateau fractures.