ArticleFrontiers in cellular and infection microbiology2025
Immune microenvironment-dependent effects of age-associated
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Apical Periodontitis May Exacerbate Ulcerative Colitis via Neutrophil Extracellular Trap-Mediated Systemic Inflammation and Intestinal Barrier Disruption in Mice.International endodontic journal · 2026Article
- Young Human-Derived Microbiota Ameliorates Cognitive Decline and Reproductive Senescence in Aged Mice.Nutrients · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The applications of probiotics in food and infant formula are greatly increased. Methods: Our present study investigates the immunomodulatory effects of two Results: Transcriptomic analysis in the DSS-induced colitis model revealed differential gene expression, particularly in cytokine signaling pathways and γ-chain-related cytokines crucial for γδ T cell function. Both BA and BI reduced γδ T cell infiltration in colorectal tissues, and modulated immune activation markers, with distinct effects on peripheral blood γδ T cell levels. RNA-seq analysis post-probiotic treatment highlighted strain-specific changes, with BA activating NOD2-like receptor signaling and BI enhancing IL-17 and TNF signaling pathways. Direct co-culture experiments demonstrated BI's robust activation of γδ T cells, while BA showed minimal direct effects. Multi-omics correlation analysis suggested that BA and BI modulated immune responses through microenvironment-dependent mechanisms, offering potential therapeutic insights for gut-related inflammatory diseases. Conclusions: Our findings provide a theoretical basis for the development of age-associated probiotic intervention strategies, offering new insights into personalized microbiota modulation to enhance immune health and gut homeostasis across different life stages.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.