ReviewMaterials today. Bio2025
Recent advances in metal ions overloading for tumors: Mechanisms, nanomaterials, and therapies.
Review in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Advances in ultrasound-mediated nanozyme systems in therapeutic applications.Ultrasonics sonochemistry · 2026Review
- Multicomponent coordination-driven self-assembled metallacycles as efficient photosensitizers for photodynamic therapy.Journal of pharmaceutical analysis · 2026Article
- NIR-responsive cetuximab-functionalized chitosan-polydopamine hydrogel Co- delivering CaJournal of biological engineering · 2026Article
- Metal overload synergy induces cell death in gastric cancer.Cell death and differentiation · 2026Article
- Metal ions in aging and ocular diseases: biology, pathophysiology, and therapeutic strategies.npj aging · 2026Review
- Cancer and Environmental Xenobiotics: Mechanisms, Controversies, and Innovations.Journal of xenobiotics · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metal ions serve as indispensable regulators in fundamental biological processes, maintaining critical physiological functions including osmotic equilibrium, acid-base regulation, intracellular signaling, and biomolecular recognition. Perturbations of ionic homeostasis can disrupt cellular integrity, leading to functional impairment and ultimately programmed cell death. Capitalizing on this paradigm, emerging nanotherapeutic approaches have pioneered the strategic induction of tumor-selective ions overloading as a potent anticancer strategy. This comprehensive review critically evaluates the roles of key metal ions (Na
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.