ArticleFrontiers in nutrition2025
Micronutrient status and fatty acid profile of adults with SARS-CoV-2 infection-an observational study.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: SARS-CoV-2 infection is a complex disease with multiple dimensions, involving factors that promote infection and virus-driven processes in many body organs. The micronutrient status, beyond others, acts as a potential confounder, influencing susceptibility to infection and disease severity. Additionally, the virus appears to alter lipid metabolism, which may serve a dual function, suppor viral replication while simultaneously contributing to the body's defense and repair mechanisms. Methods: This observational study compared micronutrient levels (vitamin D, selenium, zinc, magnesium, and iron) and lipid profiles between 139 SARS-CoV-2 -positive patients (62 hospitalized, 77 home care) and 314 healthy controls, using dried blood spots. We also examined differences by treatment setting (hospitalized vs. home care) as a proxy for disease severity. Results: Patients with SARS-CoV-2 infection exhibited similar micronutrient levels but showed a significantly impaired lipid profile compared to healthy controls. Notably, there was a significant decrease in palmitic (p-value < 0.01) and stearic acid levels ( Discussion: These findings suggest that SARS-CoV-2 infection alters lipid metabolism and that lower micronutrient status may be linked to greater disease severity.
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