Evidence map›Paper›PMID 41036177›Full record

ArticleBrain communications2025

Systemic increase of AMPA receptors associated with cognitive impairment of long COVID.

Yu Fujimoto, Hiroki Abe, Tsuyoshi Eiro, Sakiko Tsugawa, Meiro Tanaka, Mai Hatano, Waki Nakajima, Sadamitsu Ichijo, Tetsu Arisawa, Yuuki Takada and 6 more

Abstract read
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Yu FujimotoDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.ORCID https://orcid.org/0009-0004-0664-9529
Hiroki AbeDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Tsuyoshi EiroDepartment of Psychiatry, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Sakiko TsugawaDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Meiro TanakaDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Mai HatanoDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Waki NakajimaDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Sadamitsu IchijoDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Tetsu ArisawaRadioisotope Research Centre, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Yuuki TakadaDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Kimito KimuraDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Akane SanoDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Koichi HirahataHirahata Clinic, Tokyo 150-0002, Japan.
Nobuyuki SasakiDepartment of Rehabilitation Medicine, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan.
Yuichi KimuraFaculty of Informatics, Cyber Informatics Research Institute, Kindai University, Higashi-Osaka 577-8502, Japan.
Takuya TakahashiDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.ORCID https://orcid.org/0000-0001-6523-0622

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long COVID primarily presents with persistent cognitive impairment (Cog-LC), imposing a substantial and lasting global burden. Even after the pandemic, there remains a critical global need for diagnostic and therapeutic strategies targeting Cog-LC. Nevertheless, the underlying neural mechanisms remain poorly understood. Given the central role of synapses in brain function, investigation of synaptic molecular changes may provide vital insights into Cog-LC pathophysiology. In this study, we used [

Indexed as

cognitive impairmentCOVID-19long COVIDpositron-emission tomography (PET)α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA receptor)

Identifiers

PMID41036177
PMCPMC12483584

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.