Evidence map›Paper›PMID 41036053›Full record

ArticleSurgical neurology international2025

Early recurrence of olfactory neuroblastoma: A case report and literature review.

Alex Roman, Moisés Augusto de Araújo, Rudolfh Batista Arend, Bruno Zilli Peroni, Daniel Felipe Savaris, Renata Dos Santos Rabello, Victor Luiz Ferreira Kauer, Filipe Virgilio Ribeiro

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Surgical neurology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alex RomanFederal University of the Southern Frontier, Rio Grande do Sul, Brazil.
Moisés Augusto de AraújoDepartment of Neurosurgery, Institute of Neurosurgery and Spine Surgery, Rio Grande do Sul, Brazil.
Rudolfh Batista ArendDepartment of Medicine, Federal University of the Southern Frontier, Passo Fundo, Brazil.
Bruno Zilli PeroniDepartment of Medicine, Federal University of the Southern Frontier, Rio Grande do Sul, Brazil.
Daniel Felipe SavarisDepartment of Medicine, Federal University of the Southern Frontier, Rio Grande do Sul, Brazil.
Renata Dos Santos RabelloDepartment of Medicine, Federal University of the Southern Frontier, Rio Grande do Sul, Brazil.
Victor Luiz Ferreira KauerDepartment of Medicine, Federal University of the Southern Frontier, Passo Fundo, Brazil.
Filipe Virgilio RibeiroDepartment of Medicine, Barão de Mauá University Center, Faculty of Medicine, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Olfactory neuroblastoma (ONB) is a rare malignant tumor of the sinonasal cavity, often presenting with nonspecific symptoms and requiring complex multidisciplinary management. Case Description: A 55-year-old male developed progressive anosmia and recurrent epistaxis. Imaging revealed an invasive lesion involving the nasal cavity, paranasal sinuses, and intracranial space, along with cervical lymph node metastases. Diagnosis was confirmed histologically. Patient underwent craniofacial approach, cervical lymphadenectomy, and adjuvant radiotherapy. Despite aggressive treatment, early recurrence occurred in both nasal and intracranial compartments. With curative options exhausted, the patient was transitioned to palliative care. Conclusion: ONB has a high risk of recurrence, typically occurring years after initial treatment. However, early recurrence, as seen in this case, is rare and associated with aggressive tumor features such as high-grade histology and incomplete resection. These cases present significant therapeutic challenges and underscore the importance of close surveillance and further research into optimal management strategies for early recurrent ONB.

Indexed as

Micro neurosurgeryOlfactory neuroblastomaOncologyParanasal sinus tumorRadiotherapy

Identifiers

PMID41036053
PMCPMC12482727

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.