ArticleOpen veterinary journal2025
Host-parasite interaction in latent cerebral toxoplasmosis: The role of cytokine response in a mouse model.
Article in Open veterinary journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Aim: This study aimed to evaluate infection severity, affected immune cell populations, and cytokine response in both early and late chronic phases of T. gondii infection. Methods: A murine model was developed by infecting C57BL/6 mice with a sub-infective dose (104 tachyzoites) of the ME49 strain. Forty mice were used: 30 infected and 10 controls. Animals were sacrificed on days 30, 60, and 180 after infection. Brains were analyzed using histopathology, immunohistochemistry, and nested polymerase chain reaction (PCR). Results: Histopathological changes, including gliosis, meningitis, vasculitis, and neuronal degeneration, were most prominent on days 30 and 60 and decreased by day 180. Immunohistochemistry revealed dynamic changes in immune cell populations (CD4 Conclusion: This model shares several immunopathological features with chronic cerebral toxoplasmosis observed in immunocompetent humans, modeling aspects of the infection even in the absence of demonstrable tissue cysts. The immunological shift from pro-inflammatory to regulatory responses highlights the mechanisms of immune modulation and persistence. This study provides a useful platform to explore host-pathogen interactions and CNS immune dynamics in chronic cerebral toxoplasmosis.
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