Evidence map›Paper›PMID 41035949›Full record

ArticleAJPM focus2025

Do Communities Implementing the Communities That HEAL Intervention Have Significantly Lower Rates of High-Risk Opioid Prescribing and Dispensing?

Frances R Levin, Douglas R Oyler, Denise C Babineau, Jennifer Villani, Redonna K Chandler, Patricia R Freeman, Daniel P Alford, Naleef Fareed, Nicole Mack, Trang Q Nguyen and 34 more

Abstract read
In one paragraph

Article in AJPM focus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors.

Frances R LevinColumbia University Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.
Douglas R OylerDepartment of Pharmacy Practice and Science, College of Pharmacy, University of Kentucky, Lexington, Kentucky.
Denise C BabineauRTI International, Research Triangle Park, North Carolina.
Jennifer VillaniNational Institute on Drug Abuse, NIH, Bethesda, Maryland.
Redonna K ChandlerNational Institute on Drug Abuse, NIH, Bethesda, Maryland.
Patricia R FreemanDepartment of Pharmacy Practice and Science, College of Pharmacy, University of Kentucky, Lexington, Kentucky.
Daniel P AlfordSection of General Internal Medicine, Boston Medical Center, Boston, Massachusetts.
Naleef FareedDepartment of Biomedical Informatics, The Ohio State University College of Medicine, Columbus, Ohio.
Nicole MackRTI International, Research Triangle Park, North Carolina.
Trang Q NguyenNew York State Department of Health, Albany, New York.
Daniel M WalkerDepartment of Family and Community Medicine, College of Medicine, The Ohio State University, Columbus, Ohio.
Joella AdamsRTI International, Research Triangle Park, North Carolina.
Trevor J BakerSection of General Internal Medicine, Boston Medical Center, Boston, Massachusetts.
Donna BeersSection of General Internal Medicine, Boston Medical Center, Boston, Massachusetts.
Shoshana N BenjaminColumbia University School of Social Work, Columbia University, New York, New York.
Jennifer BhuiyanDepartment of Pharmacy Practice, College of Pharmacy and Health Sciences, St. John's University, New York City, New York.
Derek BlevinsColumbia University Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.
James L DavidColumbia University School of Social Work, Columbia University, New York, New York.
Netrali DalviMassachusetts Department of Public Health, Boston, Massachusetts.
Lauren D'CostaRTI International, Research Triangle Park, North Carolina.
Daniel J FeasterMiller School of Medicine, University of Miami, Miami, Florida.
LaShawn GlasgowRTI International, Research Triangle Park, North Carolina.
Dawn A Goddard-EckrichColumbia University School of Social Work, Columbia University, New York, New York.
Yi HanNew York State Department of Health, Albany, New York.
Mallory HarrisRTI International, Research Triangle Park, North Carolina.
Timothy HuntColumbia University School of Social Work, Columbia University, New York, New York.
Charles KnottRTI International, Research Triangle Park, North Carolina.
Adrienne MatsonDepartment of Pharmacy Practice and Science, College of Pharmacy, University of Kentucky, Lexington, Kentucky.
Frank MierzwaRTI International, Research Triangle Park, North Carolina.
Lisa NewmanRTI International, Research Triangle Park, North Carolina.
Edward V NunesColumbia University Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.
Emmanuel A OgaRTI International, Research Triangle Park, North Carolina.
Monica F RobertsSubstance Use Priority Research Area, University of Kentucky, Lexington, Kentucky.
Aimee ShadwickRecoveryOhio, Columbus, Ohio.
Abigail ShobenDivision of Biostatistics, College of Public Health, The Ohio State University, Columbus, Ohio.
Svetla SlavovaDepartment of Biostatistics, University of Kentucky, Lexington, Kentucky.
Laura StinsonMiller School of Medicine, University of Miami, Miami, Florida.
Gary A ZarkinRTI International, Research Triangle Park, North Carolina.
Bridget FreisthlerCollege of Social Work, The Ohio State University, Columbus, Ohio.
Jeffrey H SametBoston University School of Medicine, Boston University, Boston, Massachusetts.
Sharon L WalshDepartment of Behavioral Science, College of Medicine, University of Kentucky, Lexington, Kentucky.
T John WinhusenCenter for Addiction Research, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Rebecca D JacksonThe Ohio State University, Columbus, Ohio.
Nabila El-BasselColumbia University School of Social Work, Columbia University, New York, New York.

Funding

MassHEAL - Reducing overdose deaths by 40% (2019-2023)UM1DA049412 · NIDA · BOSTON MEDICAL CENTER · PI SAMET, JEFFREY H. · 2019 to 2023
$82.9M
Kentucky CAN HEAL (Communities and Networks Helping End Addiction Long-term)UM1DA049406 · NIDA · UNIVERSITY OF KENTUCKY · PI WALSH, SHARON L. · 2019 to 2022
$81.7M
CHASE: An Innovative County-Level Public Health Response to the Opioid Epidemic in New York StateUM1DA049415 · NIDA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI EL-BASSEL, NABILA, GILBERT, LOUISA · 2019 to 2023
$77.3M
Optimizing HEALing in Ohio Communities (OHiO)-Health Equity SupplementUM1DA049417 · NIDA · OHIO STATE UNIVERSITY · PI FREISTHLER, BRIDGET J, WINHUSEN, T JOHN · 2019 to 2023
$66.3M
HEALing Communities Study Health Equity ResearchUM1DA049394 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI GLASGOW, LASHAWN, KNOTT, CHARLES · 2019 to 2023
$40.6M
NIDA NIH HHS UM1 DA049394NIDA NIH HHS UM1 DA049406NIDA NIH HHS UM1 DA049412NIDA NIH HHS UM1 DA049415NIDA NIH HHS UM1 DA049417
6 · The paper itself

Abstract

Introduction: Prescription opioids can contribute to risk for opioid use disorder and overdoses. Improving prescription opioid safety is a critical component in reducing opioid risks. This report aims to determine whether communities randomized to the Communities That HEAL (CTH) intervention have significantly different rates of prescription opioid safety measures. Study Design: A multisite, 2-arm, community-level, cluster randomized, unblinded, wait-list controlled comparison trial designed to assess the effectiveness of the CTH intervention in reducing opioid-related overdose deaths among community residents 18 years of age or older (adults). Setting/Participants: Sixty-seven (67) communities in Kentucky, Massachusetts, New York, and Ohio. Participants were communities in this study. Intervention: The Communities That Heal intervention consists of multiple dimensions: a coalition-driven community engagement process to select and support implementation of evidence-based practices; the Opioid-overdose Reduction Continuum of Care Approach, a compendium of evidence-based practices and technical assistance resources organized under overdose education and naloxone distribution, medication for opioid use disorder, and prescription opioid safety menus; and communication campaigns intended to reduce opioid use disorder stigma and raise awareness and demand for naloxone and medication for opioid use disorder. Main Outcomes and Measures: The main outcome was the number of adults with new incident high-risk opioid prescribing episodes after at least a 45-day washout. Other outcomes included the number of opioid-naïve adults with new opioid prescriptions limited to a 7-day supply, number of adults who received opioid prescriptions from multiple prescribers or pharmacies, and number of locations providing drug take-back services. Outcomes were assessed from July 2021 to June 2022. Results: There was no statistically significant difference in the adjusted rates for new incident high-risk opioid prescribing per 100,000 adults during the comparison period between intervention (1,094.48; 95% CI=1,063.15; 1,126.74) and wait-list control communities (1,121.90; 95% CI=1,079.62; 1,165.84). The adjusted relative rate comparing intervention to wait-list control communities was 0.98 (95% CI=0.93, 1.02; Conclusions: Although no statistically significant differences were found in prescription opioid safety measures between study arms, improvement in these measures during the comparison period for both study arms suggested that there may have events outside the trial, such as published revised Center for Disease Control and Prevention clinical practice guidelines for prescribing opioids, that may have impacted study outcomes.

Indexed as

controlled substance disposalHEALing Communities StudyHigh-risk opioid prescribingPrescription Drug Monitoring Programs (PDMPs)prescription opioid safety

Identifiers

PMID41035949
PMCPMC12480870

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.