ArticleBulletin of emergency and trauma2025
Effects of Intravenous Lidocaine on Airway Complications and Hemodynamic Stability Following Emergency Laparoscopic Cholecystectomy: A Randomized Controlled Trial in Different Age Groups.
Article in Bulletin of emergency and trauma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Objectives: This randomized controlled trial aimed to evaluate the effect of pre-extubation intravenous lidocaine (1 mg/Kg) on the incidence of airway complications and hemodynamic stability in patients undergoing emergency laparoscopic cholecystectomy, while accounting for age differences. Methods: The study was a prospective, single-center, randomized controlled trial conducted from 2021 to 2023 at Imam Khomeini Hospital, Ilam, Iran. Ninety patients undergoing emergency laparoscopic cholecystectomy were classified into two age groups (<50 and ≥50 years) and randomly assigned to receive either intravenous lidocaine (1 mg/Kg) or a standard extubation protocol. The primary outcomes included post-extubation airway complications, such as laryngospasm, cough, and sore throat, and the secondary outcomes included hemodynamic and respiratory parameters. Results: Lidocaine produced hemodynamic effects that differed by age group. In patients <50 years, systolic blood pressure (SBP) increased from 129.2±16.4 mmHg to 133.1±23.1 mmHg, while diastolic blood pressure (DBP) rose from 83.9±14.4 mmHg to 92.3±19.4 mmHg (both Conclusion: Intravenous lidocaine was safe and demonstrated a trend toward reducing airway complications at extubation in patients undergoing emergency laparoscopic cholecystectomy, particularly in elderly patients. However, this trend did not reach statistical significance, most likely due to insufficient statistical power.
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