Evidence map›Paper›PMID 41035913›Full record

ReviewFrontiers in pharmacology2025

Promising therapeutics of enterovirus 71 infection: sunshine behind cloud.

Sheng-Yu You, Shun-Hua Chen, Shih-Min Wang

Abstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sheng-Yu YouDepartment of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Shun-Hua ChenDepartment of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Shih-Min WangCenter of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Enterovirus 71 (EV71) infection gave a hard hit on young children because of fatal complication, brainstem encephalitis with pulmonary edema. The occurrence of severe EV71 infections highlight the urgent need for the development and repurposing of novel antivirals for medical use. Drugs target specific steps in the cycle of viral replication, and the modification of existing factors in EV71 immunopathogenesis deciphers the current approaches for developing antivirals. In addition to identifying chemical compounds, we highlight active constituents and explore underlying mechanisms of action of antimicrobial peptides and natural products that may be active against EV71 and provide pharmacological benefits.

Indexed as

antiviralbrainstem encephalitisenterovirus 71entroviruspulmonary edema

Identifiers

PMID41035913
PMCPMC12479401

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.