ArticleFrontiers in microbiology2025
The global state, trajectory and trends of bacterial extracellular vesicles: a bibliometric and visualized analysis.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Bacterial extracellular vesicles: emerging players in antimicrobial resistance and clinical translation.Molecular biology reports · 2026Review
- Bacterial Extracellular Vesicles in Biomedical Research and Clinical Translation.Microbial biotechnology · 2026Review
- Bacterial outer membrane vesicles as intrinsically immunogenic and highly modifiable nanocarriers for precision tumor therapy.Molecular biology reports · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Bacterial extracellular vesicles (BEVs) are nanoscale biological vesicles secreted by bacteria that carry unique cargo and membrane structures derived from their parental bacteria. In recent years, BEVs have been shown to significantly contribute to the pathogenesis and progression of various diseases, with promising potential as immunotherapeutic agents, drug delivery systems, and nano-vaccines. Methods: This study aims to comprehensively evaluate the research status and development trends of BEVs using bibliometric approaches. A total of 2,836 publications indexed in the Web of Science Core Collection by 30 November 2024 were included in this study. The R package "Bibliometric" and CiteSpace software were employed for bibliometric analysis and visualization of authors, countries/regions, institutions, journals, subject categories, keywords, and references. Results: From 2006 to 2024, the number of publications exhibited a steady upward trend, with an annual growth rate of 15.01%. The USA and the Chinese Academy of Sciences were identified as the most productive country and institution, respectively. Gho, Yong Song emerged as the most prolific and influential researcher. Cluster analysis of references revealed that outer membrane vesicles, immunotherapy and probiotics are the three largest research clusters. Keyword burst detection identified cancer immunotherapy, the tumor microenvironment, and drug delivery as promising research directions. Conclusion: Our study highlights that BEV-based drug delivery systems are a major focus of current research, with tremendous potential. Future research on BEVs is expected to focus on tumor immunotherapies and remodeling of the tumor immune microenvironment. With the advancements in nanotechnology, biomedicine, and industry, BEVs are anticipated to make remarkable strides and greatly contribute to solving challenging clinical issues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.