Evidence map›Paper›PMID 41035825›Full record

ReviewFrontiers in aging neuroscience2025

Functional Cognitive Disorder: diagnostic challenges, clinical features, and future directions in a misunderstood condition.

Ioannis Mavroudis, Foivos Petridis, Katerina Franekova, Malina Visternicu, Viorica Rarinca, Vasile Burlui, Alin Ciobica, Bogdan Novac, Irina Dobrin, Mihai Marian Hogas and 3 more

Abstract readReview
In one paragraph

Review in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Dementia risk factors and biomarkers in subjective cognitive decline: real world evidence from the monza brain health service.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ioannis MavroudisDepartment of Neuroscience, Leeds Teaching Hospitals, NHS Trust, Leeds, United Kingdom.
Foivos PetridisThird Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Katerina FranekovaSchool of Medicine, University of Leeds, Leeds, United Kingdom.
Malina VisternicuFaculty of Biology, Doctoral School of Biology, "Alexandru Ioan Cuza" University of Iaşi, Iaşi, Romania.
Viorica RarincaFaculty of Biology, Doctoral School of Biology, "Alexandru Ioan Cuza" University of Iaşi, Iaşi, Romania.
Vasile Burlui"Ioan Haulica" Institute, Apollonia University, Iaşi, Romania.
Alin CiobicaAcademy of Romanian Scientists, Bucureti, Romania.
Bogdan NovacFaculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", Iaşi, Romania.
Irina DobrinCENEMED Platform for Interdisciplinary Research, "Grigore T. Popa" University of Medicine and Pharmacy of Iasi, Iaşi, Romania.
Mihai Marian HogasFaculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", Iaşi, Romania.
Erica Bovari"Ioan Haulica" Institute, Apollonia University, Iaşi, Romania.
Cristina AlbertPreclinical Department, Apollonia University, Iaşi, Romania.
Dimitrios KazisSchool of Medicine, University of Leeds, Leeds, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Functional Cognitive Disorder (FCD), a condition marked by significant subjective cognitive complaints in the absence of identifiable neurological disease, is increasingly recognized as a distinct and underdiagnosed entity in clinical practice. This review synthesizes recent findings to clarify its diagnostic features, differentiate it from other cognitive syndromes such as mild cognitive impairment and dementia, and explore its psychological underpinnings. We examined longitudinal studies, meta-analyses, and clinical frameworks to identify patterns of symptom presentation, cognitive performance, and psychosocial factors. Findings reveal that FCD is characterized by inconsistent cognitive deficits, preserved functional independence, and heightened help-seeking behavior, often accompanied by anxiety, metacognitive dysfunction, and maladaptive beliefs about memory. Unlike neurodegenerative conditions, FCD follows a stable, non-progressive course and shows no evidence of conversion to dementia when accurately diagnosed. Enhanced clinical recognition and structured assessment approaches are crucial for improving diagnostic accuracy, minimizing patient distress, and avoiding unnecessary medical interventions. Further research is needed to standardize diagnostic criteria and develop targeted therapeutic strategies.

Indexed as

diagnosisFunctional Cognitive Disorderinternal inconsistencymemory complaintsmetacognitionneuropsychiatrypseudodementiasubjective cognitive decline

Identifiers

PMID41035825
PMCPMC12479420

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.