ArticlePhysics and imaging in radiation oncology2025
Development and characterization of phantoms to investigate the Flash effect with
Article in Physics and imaging in radiation oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Deciphering Ultra-High Dose Rate Irradiation withAntioxidants (Basel, Switzerland) · 2026Article
- Development and application ofPhysics and imaging in radiation oncology · 2026Article
- New modalities for ultra-high dose rate irradiation and FLASH experiments.Physics and imaging in radiation oncology · 2025Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and purpose: Ultra-high dose rate (UHDR) radiotherapy may widen the therapeutic window thanks to the Flash effect. Experimental linear accelerators have been converted to UHDR to collect pre-clinical evidence. Increasing the accessibility, throughput and investigating additional biological endpoints is key for deciphering the mechanism of the Flash effect. The aim of this study was to develop and characterise an experimental platform for UHDR experiments with Materials and methods: A clinical linear accelerator was modified to deliver 16 MeV electron beams in UHDR and conventional (CONV) mode. Two phantoms were developed to irradiate Results: The electron UHDR irradiations provided average dose rates in the range of 200---7500 Gy/s. The beam spatial uniformity within a single vial was better than ± 5 %. The dose delivered to Conclusions: This high-throughput experimental platform on a converted clinical linear accelerator could be used to compare CONV to UHDR for up to 500 animals per week for biological endpoints at up to 1000 Gy. The production of photon megavoltage UHDR radiation was also demonstrated for the first time at a converted clinical linac.
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