Evidence map›Paper›PMID 41035777›Full record

ArticleMolecular therapy. Oncology2025

Complex genetic landscape in CLL: Clinical impact on patients' survival and insights into the altered molecular pathways.

Carlo Caputo, Massimo Donadelli, Mariateresa Scupoli, Giovanni D'Arena, Giuseppe Pietrantuono, Aldo Giudice, Angela Giliberti, Silvestro Volpe, Rossella Sperlongano, Domenico Cautela and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Carlo CaputoDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Massimo DonadelliDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy.
Mariateresa ScupoliDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy.
Giovanni D'ArenaHematology and Immunohematology and Trasfusional Medicine, ASL Salerno, Italy.
Giuseppe PietrantuonoHematology and Stem Cell Transplantation Unit, IRCCS Oncology Reference Center of Basilicata, 85028 Rionero in Vulture, Italy.
Aldo GiudiceDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84081 Salerno, Italy.
Angela GilibertiU.O.S.D. Immunohematology and Transfusional Medicine, A.O.R.N. Moscati, 83100 Avellino, Italy.
Silvestro VolpeU.O.S.D. Immunohematology and Transfusional Medicine, A.O.R.N. Moscati, 83100 Avellino, Italy.
Rossella SperlonganoDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Domenico CautelaDepartment of Theoretical and Applied Sciences, eCampus University, 22060 Novedrate, Italy.
Bernardina ScafuriDepartment of Chemistry and Biology University of Salerno, 84084 Fisciano, SA, Italy.
Angelo FacchianoNational Research Council, Institute of Food Science, 83100 Avellino, Italy.
Alessia Maria CossuDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Marco BocchettiLaboratory of Precision and Molecular Oncology, Institute of Genetic Research, Biogem Scarl, 83031 Ariano Irpino, Italy.
Gabriella MissoDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Angela LombardiDepartment of Theoretical and Applied Sciences, eCampus University, 22060 Novedrate, Italy.
Michele CaragliaDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Anna GrimaldiU.P. Cytometric and Mutational Diagnostics, Vanvitelli Hospital, University of Campania "Luigi Vanvitelli", 83031 Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic lymphocytic leukemia (CLL) is characterized by a remarkably complex landscape. We performed a molecular characterization of liquid biopsies from 137 leukemia samples and 10 healthy subjects. Almost all patients express single-nucleotide polymorphism (SNP) mutations of the

Indexed as

chemoimmunotherapyCLLgenomic aberrationsmolecular structureMT: Regular Issuemutational profilesequencingsurvival

Identifiers

PMID41035777
PMCPMC12481919

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.