SynthesisFrontiers in cardiovascular medicine2025
Prognostic value of left atrial strain in significant aortic valve disease: a systematic review and meta-analysis.
Synthesis in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Prognostic Role of Left Atrial Reservoir Strain for Risk Stratification in Aortic Stenosis: A Systematic Review.Journal of clinical medicine · 2026Review
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Previous studies on aortic valve disease have mainly focused on the left ventricle, but increasing evidence suggests that left atrial strain also has prognostic value in significant aortic valve disease. Objective: To systematically evaluate the prognostic value of left atrial strain in significant aortic valve disease. Methods: Multiple electronic databases were searched for studies evaluating significant aortic stenosis (AS) or aortic regurgitation (AR) using peak left atrial longitudinal strain (PALS) from the inception of each database to 1 February 2025. There were no language or regional restrictions. The primary endpoint was a composite outcome comprising all-cause mortality, hospitalization for heart failure, aortic valve replacement, pulmonary hypertension, and postoperative new-onset atrial fibrillation. Results: A total of 25 studies were included, involving 7,195 patients, with 2,039 (28%) patients experiencing primary endpoint events. The PALS was lower in the positive group (EVENT+) compared to the negative group (EVENT-) (SMD = -1.03, 95% CI [-1.22, -0.84], Conclusion: PALS is an independent predictor of adverse cardiovascular events in patients with significant aortic valve disease. PALS has certain value in the prognosis of significant aortic valve disease. Systematic Review Registration: [www.crd.york.ac.uk/prospero/], identifier [CRD 42024623883].
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.