ReviewFrontiers in immunology2025
The innate immune axis drives aortic dissection pathogenesis through inflammation and presents novel therapeutic targets.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Human Transcriptomic Meta-Analysis Identifies Immune-Redox Remodeling and Impaired Vascular Wall Homeostasis in Abdominal Aortic Aneurysm.International journal of molecular sciences · 2026Pooled it
- Preoperative HALP index as a predictor of in-hospital mortality after type A aortic dissection surgery: a retrospective cohort study.Annals of medicine · 2026Article
- Molecular mechanisms of programmed cell death in aortic dissection and advances in clinical translation.Molecular biology reports · 2026Review
- LINC00152/miR-145-5p/KLF4 ceRNA Axis: Diagnostic and Prognostic Value in Aortic Dissection.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2026Article
- Mechanotransduction in Marfan Syndrome and Related Aortic Disorders: Insights from Transcriptomic Analyses.Genes · 2026Review
- Quality and reliability of aortic dissection-related health information on TikTok and Bilibili: a cross-sectional content analysis study.Journal of thoracic disease · 2026Article
- Single-Cell Transcriptomics Identifies a Pivotal Role of SPHK1Inflammation · 2026Article
- Machine learning prediction of postoperative acute kidney injury in aortic dissection patients using dynamic inflammatory markers and clinical features.BMC medical informatics and decision making · 2026Article
- Prognostic Value of a Composite Inflammation-Renal Function Score in Type A Aortic Dissection.Journal of cardiovascular development and disease · 2026Article
- Elevated admission C-reactive protein identifies complicated or high-risk acute Stanford type B aortic dissection.Frontiers in immunology · 2026Observational
- Neutrophil-to-albumin ratio predicts 30-day mortality in acute aortic dissection: a retrospective cohort study.Frontiers in cardiovascular medicine · 2026Article
- Aortic dissection as a disease of vascular wall homeostasis: integrating vasa vasorum-inflammation-metabolism axis for mechanistic insight and clinical translation.Frontiers in immunology · 2026Review
- Research progress on the mechanisms of cGAS-STING signaling in immune cell infiltration associated with vascular remodeling.Journal of translational medicine · 2025Review
Corrections and comments
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7 authors.
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Abstract
Acute aortic dissection (AAD) is a life-threatening cardiovascular emergency characterized by aortic layer separation and false lumen formation, with high mortality rates. Emerging evidence highlights the critical role of innate immunity in AD pathogenesis. Innate immune activation drives AAD progression through multiple mechanisms, including macrophage polarization (M1/M2 imbalance), neutrophil extracellular trap (NET) formation, and inflammasome activation. These processes amplify vascular inflammation via cytokine storms (IL-1β, IL-6, TNF-α) and oxidative stress, further promoting matrix metalloproteinase activation and smooth muscle cell phenotypic switching. The cGAS-STING pathway, triggered by mitochondrial DNA release, and TLR signaling act as central hubs connecting vascular injury to innate immune responses. This review synthesizes recent advances in the molecular mechanisms of AAD, focusing on aortic wall structural alterations, dysregulated signaling pathway, including TGF-β, Ang II, STING, and TLR cascades, and immune-inflammatory responses mediated by innate immune components. A deeper understanding of these innate immune components may lead to improved diagnostic biomarkers and targeted therapies for AAD management.
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