Evidence map›Paper›PMID 41035546›Full record

ArticleArchive of clinical cases2025

Insulinoma initially misdiagnosed as migraine.

Javeria Hameed, Irbaz Ahmed, Abed M Zaitoun, Ammar Salman Syed, Claudia Santos, Carolyn Chee

Abstract readCase Reports
In one paragraph

Article in Archive of clinical cases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Javeria HameedDepartment of Acute Medicine, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK.
Irbaz AhmedDepartment of Accident and Emergency, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK.
Abed M ZaitounDepartment of Cellular Pathology, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK.ORCID https://orcid.org/0000-0003-3351-6460
Ammar Salman SyedDepartment of Cancer Care, Southampton General Hospital, University Hospital Southampton, Southampton, UK.
Claudia SantosDepartment of Cellular Pathology, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK.
Carolyn CheeDepartment of Diabetes and Endocrinology, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK.ORCID https://orcid.org/0000-0001-7180-2885

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Insulinoma is a rare functional neuroendocrine tumor of pancreatic islet cells that produces excessive insulin leading to neuroglycopenic and autonomic symptoms relieved by glucose. We report a case of a 39-year-old woman with recurrent neuroglycopenic symptoms for nearly five years, initially misdiagnosed as migraine, until she presented to ED with a collapse secondary to hypoglycemia. Biochemical confirmation was obtained during a supervised 72-hour fast, with symptomatic hypoglycemia which showed lowest glucose levels of 1.7mmol/L, elevated C-peptide levels of 2,271pmol/L, high insulin levels of 83.5 mU/L and a negative sulfonylurea screen. Imaging demonstrated a large hyper enhancing pancreatic mass, confirmed by

Indexed as

Differential DiagnosisHypoglycemiaMigraine MimicNeuroendocrine TumorWhipple's Triad

Identifiers

PMID41035546
PMCPMC12481506

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.