Evidence map›Paper›PMID 41035514›Full record

ArticleSmart molecules : open access2025

Insights into the mechanism of reversible blood-brain barrier opening via second near-infrared region excited gold nanorods photothermal effect: Regulation of the tight junction protein occludin.

Kaili Liang, Li Yang, Bo Liu, Xinying Wang, Liyan Wang, Jiawei Kang, Zhang Ding, Wei Wang, Qing Wang

Abstract read
In one paragraph

Article in Smart molecules : open access, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kaili LiangDepartment of Pharmaceutical Engineering State Key Laboratory of Fine Chemicals School of Chemical Engineering Dalian University of Technology Dalian China.
Li YangDepartment of Pharmaceutical Engineering State Key Laboratory of Fine Chemicals School of Chemical Engineering Dalian University of Technology Dalian China.
Bo LiuDepartment of Pharmaceutical Engineering State Key Laboratory of Fine Chemicals School of Chemical Engineering Dalian University of Technology Dalian China.
Xinying WangDepartment of Pharmaceutical Engineering State Key Laboratory of Fine Chemicals School of Chemical Engineering Dalian University of Technology Dalian China.
Liyan WangDepartment of Pharmaceutical Engineering State Key Laboratory of Fine Chemicals School of Chemical Engineering Dalian University of Technology Dalian China.
Jiawei KangDepartment of Pharmaceutical Engineering State Key Laboratory of Fine Chemicals School of Chemical Engineering Dalian University of Technology Dalian China.
Zhang DingDepartment of Pharmaceutical Engineering State Key Laboratory of Fine Chemicals School of Chemical Engineering Dalian University of Technology Dalian China.
Wei WangDepartment of Pharmaceutical Engineering State Key Laboratory of Fine Chemicals School of Chemical Engineering Dalian University of Technology Dalian China.
Qing WangDepartment of Pharmaceutical Engineering State Key Laboratory of Fine Chemicals School of Chemical Engineering Dalian University of Technology Dalian China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study constructed an in vitro blood-brain barrier (BBB) transwell model to investigate the regulatory effects and mechanisms of the photothermal effects of gold nanorods (AuNRs) excited by the second near-infrared region (NIR-II) on BBB permeability. The experimental results showed that the photothermal effects of NIR-II + AuNRs significantly decreased

Indexed as

blood‐brain barrieroccludinprotein conformationtight junction protein

Identifiers

PMID41035514
PMCPMC12483132

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.