ArticleSmart molecules : open access2025
A ratiometric fluorescent probe monitoring lipid peroxidation within lipid droplets in foam cells.
Article in Smart molecules : open access, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed.
- A dual-responsive fluorescent probe for imaging viscosity and polarity in nonalcoholic fatty liver disease.Smart molecules : open access · 2026Article
- A lysosome-targeted ultra-sensitive viscosity probe for monitoring viscosity alterations during chemotherapy.Smart molecules : open access · 2026Article
- Near-Infrared Fluorescent Lipid Droplet Polarity Probe for Distinguishing Different Liver Injury Diseases.Chemical & biomedical imaging · 2026Article
- Bulky Group Shaping Cyanine as an Efficient Photosensitizer: A Photo-Inducer for Photodynamic Immunotherapy.JACS Au · 2025Article
- A ratiometric fluorescent probe monitoring lipid peroxidation within lipid droplets in foam cells.Smart molecules : open access · 2025Article
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Authors and funding
6 authors.
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Abstract
Lipid peroxidation (LPO) in foam cells is crucial for regulating atherosclerosis progression. It correlates with lipid uptake and the state of lipid droplets. In this study, we report a lipid droplet-targeted fluorescent LPO probe, Ld-LPO. It selectively responds to LPO, resulting in a significant fluorescence shift from 590 to 525 nm, enabling a ratiometric imaging of LPO in lipid droplets. Ld-LPO traces lipid droplets in foam cells, revealing a correlation between LPO and lysosomal engulfment. We found that lipid droplets engulfed by lysosomes exhibit higher LPO, attributed to low-density lipoprotein accumulation in lysosomes. Furthermore, Ld-LPO is compatible with dual-color flow cytometry, facilitating high-throughput analysis of LPO in foam cells.
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