Evidence map›Paper›PMID 41035483›Full record

ArticleJournal of extracellular biology2025

Generalizability of Enzyme-Based Isolation Approach for Extracellular Vesicles From Traditional Medicinal Plants.

Qian Wang, Renwei Jing, Nan Cao, Xingjie He, Zhongqiu Yang, Leijie Zhang, Yi Liu, Ruibing Chen, Beibei Xiang, Xiaodong Xie and 1 more

Erratum issuedAbstract read
In one paragraph

Article in Journal of extracellular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Qian WangState Key Laboratory of Experimental Hematology & The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics & Schools of Medical Technology & Basic Medical Sciences Tianjin Medical University Tianjin China.
Renwei JingState Key Laboratory of Experimental Hematology & The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics & Schools of Medical Technology & Basic Medical Sciences Tianjin Medical University Tianjin China.
Nan CaoState Key Laboratory of Experimental Hematology & The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics & Schools of Medical Technology & Basic Medical Sciences Tianjin Medical University Tianjin China.
Xingjie HeState Key Laboratory of Experimental Hematology & The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics & Schools of Medical Technology & Basic Medical Sciences Tianjin Medical University Tianjin China.
Zhongqiu YangState Key Laboratory of Experimental Hematology & The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics & Schools of Medical Technology & Basic Medical Sciences Tianjin Medical University Tianjin China.
Leijie ZhangState Key Laboratory of Experimental Hematology & The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics & Schools of Medical Technology & Basic Medical Sciences Tianjin Medical University Tianjin China.
Yi LiuSchool of Pharmaceutical Science and Technology Tianjin University Tianjin China.
Ruibing ChenSchool of Pharmaceutical Science and Technology Tianjin University Tianjin China.
Beibei XiangSchool of Chinese Material Medica Tianjin University of Traditional Chinese Medicine Tianjin China.
Xiaodong XieTianjin Key Laboratory of Intelligent Breeding of Major Crops College of Agronomy and Resources and Environment Tianjin Agricultural University Tianjin China.
HaiFang YinState Key Laboratory of Experimental Hematology & The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics & Schools of Medical Technology & Basic Medical Sciences Tianjin Medical University Tianjin China.ORCID https://orcid.org/0000-0001-8774-2864

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) from plants, particularly traditional medicinal plants, have garnered therapeutic interest. However, therapeutic utility requires establishing effective extraction and purification protocols for manufacturing. Here, we systemically optimized an enzyme-based EV extraction method and demonstrated the generalizability with different parts from seventeen medicinal plants, fresh, frozen or dried. The enzymatic pulping process (henceforth denoted as Phyto-EVpure) of fresh ginger,

Indexed as

enzymeEVsphloemPhyto‐EVpuretraditional medicinal plantxylem

Identifiers

PMID41035483
PMCPMC12479721

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.