Evidence map›Paper›PMID 41035469›Full record

ArticleRSC advances2025

Green synthesis of new chiral amino acid urea derivatives and evaluation of their anti-inflammatory activity.

Sirine Mehrez, Sarah Absi, Assia Hamdi, Sylvain Marque, Abderrahman Bouraoui, Yakdhane Kacem, Jamil Kraiem

Abstract read
In one paragraph

Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sirine MehrezLaboratoire de Développement Chimique, Galénique et Pharmacologique des Médicaments, Faculté de Pharmacie de Monastir, Université de Monastir Rue Avicenne 5000 Monastir Tunisia.
Sarah AbsiLaboratoire de Développement Chimique, Galénique et Pharmacologique des Médicaments, Faculté de Pharmacie de Monastir, Université de Monastir Rue Avicenne 5000 Monastir Tunisia.
Assia HamdiLaboratoire de Développement Chimique, Galénique et Pharmacologique des Médicaments, Faculté de Pharmacie de Monastir, Université de Monastir Rue Avicenne 5000 Monastir Tunisia.
Sylvain MarqueUniversité Paris-Saclay, UVSQ, CNRS, UMR 8180, Institut Lavoisier de Versailles (ILV) 45 Avenue des Etats-Unis 78 035 Versailles Cedex France sylvain.marque@uvsq.fr.ORCID https://orcid.org/0000-0002-0647-4878
Abderrahman BouraouiLaboratoire de Développement Chimique, Galénique et Pharmacologique des Médicaments, Faculté de Pharmacie de Monastir, Université de Monastir Rue Avicenne 5000 Monastir Tunisia.
Yakdhane KacemLaboratoire de Développement Chimique, Galénique et Pharmacologique des Médicaments, Faculté de Pharmacie de Monastir, Université de Monastir Rue Avicenne 5000 Monastir Tunisia.
Jamil KraiemLaboratoire de Développement Chimique, Galénique et Pharmacologique des Médicaments, Faculté de Pharmacie de Monastir, Université de Monastir Rue Avicenne 5000 Monastir Tunisia.ORCID https://orcid.org/0000-0001-8917-1022

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A practically simple, mild and efficient method is developed for the synthesis of a series of new chiral urea derivatives by nucleophilic addition of amines from natural (l)-amino acids to various aryl isocyanates in alkaline aqueous medium, without organic co-solvent and under room temperature conditions. The synthesized compounds were obtained in good to excellent yields with high chemical purity by applying simple filtration and their structures were confirmed by spectral analysis (

Identifiers

PMID41035469
PMCPMC12481247

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.