Evidence map›Paper›PMID 41035467›Full record

ArticleRSC advances2025

Sub-zero temperature biosolvent-assisted liquid-liquid microextraction for quantifying propranolol and carvedilol in human urine using HPLC-UV: greenness profile evaluation.

Styliani Nisyriou, Constantinos K Zacharis

Abstract read
In one paragraph

Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Styliani NisyriouLaboratory of Pharmaceutical Analysis, Department of Pharmacy, Aristotle University of Thessaloniki (AUTh) GR-54124 Greece czacharis@pharm.auth.gr +30 2310997663.
Constantinos K ZacharisLaboratory of Pharmaceutical Analysis, Department of Pharmacy, Aristotle University of Thessaloniki (AUTh) GR-54124 Greece czacharis@pharm.auth.gr +30 2310997663.ORCID https://orcid.org/0000-0001-9362-8523

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herein, a biosolvent-based liquid-liquid microextraction method utilizing menthol as the extraction medium is proposed for the isolation and quantification of selected β-blockers (propranolol and carvedilol) in human urine. The method is based on the addition of 65 μL of molten menthol to aqueous urine samples, followed by sonication. Phase separation was achieved by centrifugation, and the menthol-rich phase was subsequently solidified using sub-zero cooling. The aqueous layer was removed

Identifiers

PMID41035467
PMCPMC12481188

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.