Evidence map›Paper›PMID 41035462›Full record

ReviewRSC advances2025

Tellurium nanoparticles as antimicrobial agents for multi-drug-resistant infections.

Abiola Samuel Ajayi, Pelumi Adanigbo, Joshua Tunde Olaifa, Miracle Oluwabukunmi Obaleye, Emmanuella Amara Ofoka, Sunday Onyebuchi Ukanwa, Prince Duru, Fagbolade Moshood, Aireguamen I Aigbodion, Ikhazugbe Hilary Ifijen

Abstract readReview
In one paragraph

Review in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Abiola Samuel AjayiTexas Southern University 31000 Cleburne St Houston TX 77004 USA.
Pelumi AdanigboDepartment of Chemistry and Biochemistry, George Mason University Fairfax VA USA.
Joshua Tunde OlaifaDepartment of Crop Science, University of Ilesa Ilesa Osun State Nigeria.
Miracle Oluwabukunmi ObaleyeDepartment of Microbiology, University of Ilesa Ilesa Osun State Nigeria.
Emmanuella Amara OfokaDepartment of Veterinary Physiology and Pharmacology, Texas A&M University College Station Texas USA.
Sunday Onyebuchi UkanwaDepartment of Bioengineering, Cyprus International University 99258 Nicosia North Cyprus Turkey.
Prince DuruEmergency Medicine Department, University of Tennessee Medical Center 1924 Alcoa Hwy Knoxville TN 37920 USA.
Fagbolade MoshoodDepartment of Biological Sciences 219 Harned Hall Mississippi State MS 39762 USA.
Aireguamen I AigbodionDepartment of Physical Chemistry, Benson Idahosa University Benin City Edo State Nigeria.
Ikhazugbe Hilary IfijenDepartment of Research Outreach, Rubber Research Institute of Nigeria Nigeria larylans4u@yahoo.com.ORCID https://orcid.org/0000-0003-4165-5639

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rise of multi-drug-resistant (MDR) infections has driven interest in alternative antimicrobial agents, with tellurium nanoparticles (TeNPs) emerging as a promising solution. TeNPs possess unique physicochemical properties, including controlled size, shape, and surface chemistry, which contribute to their potent antimicrobial activity. Their mechanisms of action include reactive oxygen species (ROS) generation, membrane disruption, inhibition of essential microbial proteins and enzymes, and direct damage to DNA and RNA. These multifaceted interactions enable TeNPs to combat a broad spectrum of bacterial and fungal pathogens effectively. In addition to their direct antimicrobial effects, TeNPs have demonstrated efficacy in disrupting and preventing biofilm formation, a key factor in persistent infections. Their application in treating infected wounds has shown promise by reducing microbial burden while promoting wound healing. Notably, TeNPs exhibit synergistic effects when combined with conventional antibiotics, enhancing bacterial eradication and potentially mitigating resistance development. However, concerns remain regarding their cytotoxicity, biodegradability, and long-term clearance in mammalian systems. Addressing these issues through surface modifications and controlled release strategies is essential for safe biomedical applications. Despite their potential, challenges such as scalable production, stability, and regulatory approval hinder widespread use. Future research will focus on advanced functionalization to enhance selectivity, emerging applications such as biofilm disruption and antiviral therapies, and integration with smart technologies for infection monitoring. A structured roadmap for clinical translation is necessary to move TeNP-based therapies from experimental studies to medical practice. The continued development of TeNPs could revolutionize antimicrobial strategies and address the global antibiotic resistance crisis.

Identifiers

PMID41035462
PMCPMC12482987

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.