Evidence map›Paper›PMID 41035426›Full record

ArticleBioactive materials2026

Human iPSC-derived cardiac-specific extracellular matrix scaffolds for cardiomyocyte maturation and post-myocardial infarction repair.

Dhavan Sharma, Wenkai Jia, Alvis Chiu, Hee Jae Jang, Vladislav Leonov, Zhishi Chen, Brandon Zhao, Weijia Luo, Hutomo Tanoto, Jianhua Zhang and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Dhavan SharmaDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA.
Wenkai JiaDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA.
Alvis ChiuDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA.
Hee Jae JangDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Vladislav LeonovDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Zhishi ChenInstitute of Biosciences and Technology, Texas A&M University, Houston, TX, 77030, USA.
Brandon ZhaoDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA.
Weijia LuoInstitute of Biosciences and Technology, Texas A&M University, Houston, TX, 77030, USA.
Hutomo TanotoDepartment of Mechanical Engineering, Texas A&M University, College Station, TX, 77843, USA.
Jianhua ZhangDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Alexey V GlukhovDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Yong YangDepartment of Biomedical Engineering, University of North Texas, Denton, 76203, TX, USA.
Yuxiao ZhouDepartment of Mechanical Engineering, Texas A&M University, College Station, TX, 77843, USA.
Jiang ChangInstitute of Biosciences and Technology, Texas A&M University, Houston, TX, 77030, USA.
Timothy J KampDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Feng ZhaoDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA.

Funding

Novel Insights into the Mechanistic Role of Small Rho GTPase in Chronic Cardiac Fibrotic RemodelingR01HL176744 · NHLBI · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI Weijia Luo · 2025 to 2026
$1.0M
NHLBI NIH HHS R01 HL176744
6 · The paper itself

Abstract

Myocardial infarction (MI) remains a leading cause of heart failure due to the limited regenerative capacity of the adult myocardium. The therapeutic efficacy of current engineered cardiac patches is hindered by their simplistic scaffold composition and lack of structural organization. This study presents a bioactive, anisotropic extracellular matrix (ECM) scaffold derived from human induced pluripotent stem cell-differentiated cardiac fibroblasts (hiPSC-CF-ECM) that combines cardiac-specific proteins and growth factors with complex structural composition. Compared to primary cardiac fibroblast ECM (pri-CF-ECM) and human dermal fibroblast ECM (hDF-ECM), hiPSC-derived cardiomyocytes (hiPSC-CMs) cultured on the cardiac-specific ECM scaffold exhibited enhanced maturation, as confirmed by bulk RNA sequencing, electrophysiological mapping, and optical-based strain analysis. In an immune-competent rat MI model, the hiPSC-CF-ECM transplantation preserved cardiac function, increased ejection fraction, and reduced maladaptive remodeling. These findings highlight hiPSC-CF-ECM as a promising biomimetic scaffold for cardiac tissue engineering and MI treatment.

Indexed as

Anisotropic scaffoldCardiac-specific extracellular matrixCardiac tissue engineeringCardiomyocyte maturationMyocardial infarction

Identifiers

PMID41035426
PMCPMC12481509

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.