ArticleJournal of veterinary internal medicine
Evaluation of a Rapid, Low-Cost Broth Turbidity Test for Detecting Ampicillin-Resistant Lower Urinary Tract Infections in Dogs and Cats.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Evaluation of a Rapid, Low-Cost Broth Turbidity Test for Detecting Ampicillin-Resistant Lower Urinary Tract Infections in Dogs and Cats.Journal of veterinary internal medicineArticle
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Authors and funding
7 authors.
Funding
Abstract
backgroundEffective treatment of urinary tract infections (UTIs) in dogs and cats relies on timely recognition of antimicrobial resistance, but traditional microbiological culture and susceptibility testing require 48-72 h and can be cost-prohibitive.
objectiveTo evaluate a novel, low-cost broth turbidity test for detecting ampicillin-resistant UTIs in dogs and cats compared to the gold standard microbiological methods. ANIMALS: One hundred sixty urine samples from 145 dogs and 15 cats at the Mississippi State University College of Veterinary Medicine.
methodsFrom September 2023 to February 2024, urine samples were tested using an ampicillin-supplemented Mueller-Hinton broth turbidity test and gold standard culture with Sensititre MIC plates. Sensitivity, specificity, Cohen's κ, and McNemar's test were calculated.
resultsThe broth turbidity test showed 89.47% sensitivity (95% CI: 66.86%-98.72%) and 100% specificity (95% CI: 97.42%-100%) for the detection of ampicillin-resistant organisms in the urine, with substantial agreement (κ = 0.94, p < 0.001) and no classification difference (p = 0.500). Notably, all 36 samples with ampicillin-susceptible organisms identified by the gold standard cultures test were correctly identified as negative for ampicillin resistance by the broth turbidity test.
conclusionsThe broth turbidity test's simplicity and affordability make it a promising tool for in-house use by veterinary practitioners to guide first-line therapy decisions, though its sensitivity could be limited in cases with low bacterial loads or confounding factors such as recent antibiotic administration.
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