ArticleAnimal bioscience2026
BMP8A, TGF-β1 regulates chicken chondrocyte proliferation, differentiation, and apoptosis induced by Thiram.
Article in Animal bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Dietary Chlorogenic Acid-Rich Green Coffee Bean Extract Improves Laying Performance and Antioxidant Status in Heat-Stressed Laying Hens.Animals : an open access journal from MDPI · 2026Article
- Supplementation of a Dietary Probiotics Blend can Enhance Growth Performance in Guiqian Semi-Fine Wool Sheep by Modulating Rumen Microbiota and Immune Function.Probiotics and antimicrobial proteins · 2026Article
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Authors and funding
10 authors.
Funding
Abstract
objectiveTibial dyschondroplasia (TD) is a metabolic disorder of cartilage that impairs the development of the tibial growth plate in rapidly growing poultry. This study aimed to identify key genes and clarify the molecular mechanisms involved in TD in broiler chickens. The study evaluated the potential effect of vitamin D3 (VD3) in alleviating TD symptoms, focusing particularly on the role of Bone morphogenetic protein 8A (BMP8A) and its interaction with transforming growth factor-β1 (TGF-β1).
methodsNinety-four broiler chicks were allocated into three groups: healthy control, thiram-induced TD, and thiram-induced with VD3 supplementation. RNA sequencing was performed to identify differentially expressed genes (DEGs) among the groups. Target genes underwent additional validated using molecular biology techniques, such as gene expression analysis and in vitro functional assays on chondrocytes.
resultsVD3 effectively mitigated chondrocyte damage induced by thiram. RNA-seq revealed 625 DEGs enriched in pathways such as the TGF-β signaling pathway. Four co-DEGs (BMP8A, COL10A1, SDC3, and SCIN) were closely associated with collagen metabolism and reorganization. Functional assays, such as CCK8, EdU and IHC showed that BMP8A reduced collagen accumulation induced by elevated TGF-β1 levels, promoted the release of collagen types I, II, and X, and facilitated chondrocyte proliferation and differentiation while reducing apoptosis.
conclusionBMP8A plays a protective role in TD by the regulation of collagen balance and the maintenance of chondrocyte function, especially in the presence of high TGF-β1 levels. VD3 supplementation effectively reduces TD-related damage. The interaction between BMP8A and TGF-β1 may provide a novel therapeutic target for the prevention and treatment of TD in poultry.
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