ArticleAnimal bioscience2026
Transcriptome and proteome combined analysis of wool fiber diameter regulation mechanism.
Article in Animal bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThe diameter of wool fiber is a crucial phenotypic trait and a key determinant affecting its economic value. Understanding the regulatory mechanisms that influence wool fiber diameter is a fundamental approach to optimizing wool fineness.
methodsThis study involved the selection of fine-wool Alpine Merino sheep with three distinct fiber diameter ranges for detailed whole-transcriptome and proteome analyses of skin tissues.
resultsThis led to the identification of key microRNAs (oar-miR-23a, oar-miR-23b, oarmiR-150, and oar-miR-218a), critical circular RNAs (circRNA3051, circRNA0315, and circRNA_1477), and multiple pivotal genes (LOC10112037, LOC105614079, IGFBP1, IGFBP4, and MAPK9). Correlation analysis was utilized to develop a comprehensive regulatory network, revealing a close regulation of wool fiber diameter and both energy metabolism and lipid metabolism.
conclusionThis study found that the triglyceride and energy metabolic pathways as significant factors influencing of wool fiber diameter, thus offering a theoretical basis for promoting wool industry through the refinement of wool diameter and quality.
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